Genotypes responsible for interindividual differences in ability to activate or detoxify genotoxic agents are recognized as biomarkers of susceptibility. Among the most studied genotypes are human glutathione transferases. The relationship of genetic susceptibility to biomarkers of exposure and effects was studied especially in relation to the genetic polymorphism of glutathione S-transferase M1 (GSTM1). For this review papers reporting the effect of GSTM1 genotype on DNA adducts, protein adducts, urine mutagenicity, Comet assay parameters, chromosomal aberrations, sister chromatid exchanges (SCE), micronuclei, and hypoxanthine-guanine phosphoribosyl transferase mutations were assessed. Subjects in groups occupationally exposed to polycyclic aromatic hydrocarbons, benzidine, pesticides, and 1,3-butadiene were included. As environmentally exposed populations, autopsy donors, coal tar-treated patients, smokers, nonsmokers, mothers, postal workers, and firefighters were followed. From all biomarkers the effect of GSTM1 and N-acetyl transferase 2 was seen in coke oven workers on mutagenicity of urine and of glutathione S-transferase T1 on the chromosomal aberrations in subjects from 1,3-butadiene monomer production units. Effects of genotypes on DNA adducts were found from lung tissue of autopsy donors and from placentas of mothers living in an air-polluted region. The GSTM1 genotype affected mutagenicity of urine in smokers and subjects from polluted regions, protein adducts in smokers, SCE in smokers and nonsmokers, and Comet assay parameters in postal workers. A review of all studies on GSTM1 polymorphisms suggests that research probably has not reached the stage where results can be interpreted to formulate preventive measures. The relationship between genotypes and biomarkers of exposure and effects may provide an important guide to the risk assessment of human exposure to mutagens and carcinogens.

Laboratory of Genetic Ecotoxicology Institute of Experimental Medicine and Regional Institute of Hygiene of Central Bohemia Prague Czech Republic

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Mutat Res. 1991 Apr;247(2):259-66 PubMed

Mutat Res. 1991 Apr;247(2):267-81 PubMed

Cancer Res. 1991 Sep 15;51(18 Suppl):5023s-5044s PubMed

Carcinogenesis. 1991 Sep;12(9):1533-7 PubMed

Mutat Res. 1991 Sep-Oct;250(1-2):299-306 PubMed

Carcinogenesis. 1991 Dec;12(12):2269-75 PubMed

J Natl Cancer Inst. 1992 Mar 18;84(6):414-22 PubMed

Jpn J Cancer Res. 1992 Aug;83(8):866-70 PubMed

Biochem J. 1992 Sep 15;286 ( Pt 3):929-35 PubMed

Nature. 1992 Nov 19;360(6401):256-8 PubMed

Environ Health Perspect. 1992 Nov;98:87-94 PubMed

Cancer Res. 1993 Mar 1;53(5):1004-11 PubMed

Cancer Res. 1993 May 15;53(10 Suppl):2313-8 PubMed

Cancer Res. 1993 Jul 1;53(13):2994-9 PubMed

Environ Mol Mutagen. 1995;25(2):97-105 PubMed

Carcinogenesis. 1995 Apr;16(4):707-11 PubMed

Epidemiology. 1995 Mar;6(2):190-4 PubMed

Carcinogenesis. 1995 Jun;16(6):1305-9 PubMed

Cancer Res. 1995 Aug 1;55(15):3305-9 PubMed

J Occup Environ Med. 1995 Jan;37(1):37-43 PubMed

Environ Health Perspect. 1997 May;105(5):464-5 PubMed

Cancer Res. 1997 Jul 15;57(14):2839-42 PubMed

Carcinogenesis. 1997 Jul;18(7):1285-9 PubMed

Environ Health Perspect. 1997 Jun;105 Suppl 4:699-737 PubMed

Environ Health Perspect. 1997 Jun;105 Suppl 4:791-9 PubMed

Adv Enzymol Relat Areas Mol Biol. 1978;46:383-414 PubMed

Biochemistry. 1983 Jul 19;22(15):3610-7 PubMed

Carcinogenesis. 1986 May;7(5):751-3 PubMed

Am J Hum Genet. 1988 Jan;42(1):89-95 PubMed

Carcinogenesis. 1990 Jan;11(1):33-6 PubMed

Crit Rev Biochem Mol Biol. 1990;25(1):47-70 PubMed

Cancer Res. 1990 Mar 1;50(5):1585-90 PubMed

Carcinogenesis. 1990 Dec;11(12):2179-83 PubMed

Biochem J. 1991 Mar 1;274 ( Pt 2):409-14 PubMed

Carcinogenesis. 1995 Aug;16(8):1913-7 PubMed

Carcinogenesis. 1993 Jul;14(7):1479-81 PubMed

Cancer Res. 1993 Aug 1;53(15):3486-92 PubMed

Mutat Res. 1993 Oct;289(2):187-95 PubMed

Cancer Epidemiol Biomarkers Prev. 1993 Sep-Oct;2(5):441-7 PubMed

Carcinogenesis. 1994 Feb;15(2):415-8 PubMed

Cancer Res. 1994 Jun 1;54(11):2919-22 PubMed

Biochem J. 1994 May 15;300 ( Pt 1):271-6 PubMed

Carcinogenesis. 1994 May;15(5):813-5 PubMed

Carcinogenesis. 1994 Jul;15(7):1347-52 PubMed

Carcinogenesis. 1994 Sep;15(9):1785-90 PubMed

Carcinogenesis. 1994 Nov;15(11):2449-54 PubMed

Carcinogenesis. 1994 Dec;15(12):2841-5 PubMed

Mutat Res. 1995 Apr;334(2):117-24 PubMed

Cancer Genet Cytogenet. 1995 Feb;79(2):133-5 PubMed

Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):301-11 PubMed

J Natl Cancer Inst. 1995 Jun 21;87(12):902-7 PubMed

Mol Carcinog. 1995 Sep;14(1):63-8 PubMed

Epidemiology. 1995 Jul;6(4):455-7 PubMed

Cancer Epidemiol Biomarkers Prev. 1995 Jul-Aug;4(5):535-42 PubMed

Mutat Res. 1995 Oct;348(2):75-82 PubMed

Cancer Epidemiol Biomarkers Prev. 1995 Sep;4(6):589-94 PubMed

Mutat Res. 1995 Dec;335(3):267-73 PubMed

Mutat Res. 1995 Nov;332(1-2):109-18 PubMed

Cancer Res. 1996 Jan 1;56(1):72-6 PubMed

Mutat Res. 1996 Jan 17;349(1):43-50 PubMed

Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):861-4 PubMed

Carcinogenesis. 1996 May;17(5):1021-7 PubMed

Environ Mol Mutagen. 1996;27(4):263-9 PubMed

Environ Health Perspect. 1995 Nov;103 Suppl 8:233-6 PubMed

Carcinogenesis. 1996 Aug;17(8):1677-81 PubMed

Environ Health Perspect. 1996 May;104 Suppl 3:445-8 PubMed

Environ Health Perspect. 1996 May;104 Suppl 3:503-10 PubMed

Environ Health Perspect. 1996 May;104 Suppl 3:569-77 PubMed

Environ Health Perspect. 1996 May;104 Suppl 3:591-7 PubMed

Environ Health Perspect. 1996 Aug;104 Suppl 4:699-714 PubMed

Toxicology. 1996 Oct 28;113(1-3):77-83 PubMed

Int Arch Occup Environ Health. 1996;68(3):170-6 PubMed

Cancer Epidemiol Biomarkers Prev. 1996 Dec;5(12):979-83 PubMed

Carcinogenesis. 1997 Feb;18(2):345-50 PubMed

Carcinogenesis. 1997 Mar;18(3):503-9 PubMed

Mutat Res. 1997 Mar 17;389(2-3):227-35 PubMed

Mutat Res. 1997 Apr 24;390(1-2):59-68 PubMed

Mutat Res. 1997 Jun 13;391(1-2):3-32 PubMed