Endurance training increases the beta-adrenergic lipolytic response in subcutaneous adipose tissue in obese subjects
International journal of obesity and related metabolic disorders | Int J Obes Relat Metab Disord
Source
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adrenergic beta-Agonists administration & dosage MeSH
- Receptors, Adrenergic, beta physiology MeSH
- Exercise * MeSH
- Adult MeSH
- Physical Endurance * MeSH
- Glucose Tolerance Test MeSH
- Glycerol blood MeSH
- Phosphodiesterase Inhibitors administration & dosage MeSH
- Isoproterenol administration & dosage MeSH
- Fatty Acids, Nonesterified blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipids blood MeSH
- Lipolysis * MeSH
- Microdialysis MeSH
- Obesity metabolism therapy MeSH
- Theophylline administration & dosage MeSH
- Adipose Tissue metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adrenergic beta-Agonists MeSH
- Receptors, Adrenergic, beta MeSH
- Glycerol MeSH
- Phosphodiesterase Inhibitors MeSH
- Isoproterenol MeSH
- Fatty Acids, Nonesterified MeSH
- Lipids MeSH
- Theophylline MeSH
OBJECTIVE: The aim of this study was to assess, by longitudinal follow-up, the influence of aerobic training on the in vivo lipolytic activity of adipose tissue in obese male subjects. SUBJECTS: Eleven obese non-diabetic males, aged 41.5+/-5.77 (range 27-49 y) with body mass index (BMI) 36.5+/-4.5 kg/m2 (range 29.4-47.1 kg/m2) participated in the study. DESIGN: Subjects took part in a 12-week aerobic training program. Before and after training, microdialysis of abdominal subcutaneous adipose tissue (SCAT) was carried out, using perfusion with graded doses of the beta-adrenergic agonist isoprenaline and a single dose of the phosphodiesterase inhibitor theophylline. In addition, the response of plasma glycerol and free fatty acids (FFAs) to intravenous infusion of graded doses of isoprenaline was tested. RESULTS: The training did not induce significant weight loss and promoted an increase in maximum aerobic capacity (P<0.05). The increase of extracellular glycerol in SCAT in response to isoprenaline perfusion was enhanced after the training (P<0.05), while no change in the response of interstitial glycerol to theophylline action was observed. The training did not elicit a change in the isoprenaline-induced changes of blood flow in adipose tissue. The increases of plasma FFAs and glycerol in response to intravenous isoprenaline infusion, were significantly enhanced after training. CONCLUSION: The present study shows that aerobic training induced an increase in the response of plasma and subcutaneous adipose tissue concentration of glycerol to beta-adrenergic stimulation. The effect of an agent acting at the post-receptor level (theophylline) in SCAT was not modified by training.
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