A multidrug-resistant tuberculosis microepidemic caused by genetically closely related Mycobacterium tuberculosis strains
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
10405429
PubMed Central
PMC85324
DOI
10.1128/jcm.37.8.2715-2716.1999
Knihovny.cz E-zdroje
- MeSH
- DNA bakterií analýza genetika MeSH
- DNA fingerprinting MeSH
- epidemický výskyt choroby MeSH
- lidé MeSH
- mnohočetná léková rezistence MeSH
- Mycobacterium tuberculosis účinky léků genetika patogenita MeSH
- polymorfismus délky restrikčních fragmentů MeSH
- tuberkulóza epidemiologie mikrobiologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- DNA bakterií MeSH
IS6110 DNA fingerprinting was used to characterize an outbreak of multidrug-resistant tuberculosis in 21 individuals (17 males and 4 females) living in or roaming among four distantly separated areas in the Czech Republic. The restriction fragment length polymorphism (RFLP) analysis separated the collected Mycobacterium tuberculosis strains into group A, including 14 patients with six IS6110 copies, and group B, with 7 patients displaying highly similar RFLP patterns but with two additional IS6110 bands. A switch from pattern A to pattern B was observed in one patient, and the subsequent detection of subclone B in seven more individuals has been explained by the instability of DNA genotypes caused by transposition of IS6110 elements.
Zobrazit více v PubMed
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