The effect of triiodothyronine on changes of membrane fluidity in regenerating rat liver
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10534021
Knihovny.cz E-resources
- MeSH
- Cell Membrane physiology MeSH
- Membrane Fluidity drug effects MeSH
- Liver physiology ultrastructure MeSH
- Rats MeSH
- Rats, Wistar MeSH
- Liver Regeneration * MeSH
- Triiodothyronine pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Triiodothyronine MeSH
The increase of the membrane fluidity during the early phase of liver regeneration after partial hepatectomy was described in literature in plasma membrane and in microsomes. We found similar changes also in isolated mitochondria and in crude total membrane fraction of the liver homogenate. The administration of triiodothyronine to rats before partial hepatectomy diminished the increase of the membrane fluidity in the regenerating liver by 50%. Triiodothyronine effect is explained by hormonal modification of lipid metabolism in the regenerating liver.
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