Alterations in surface hydrophobicity of Acinetobacter baumannii induced by meropenem
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
10664881
DOI
10.1007/bf02818545
Knihovny.cz E-resources
- MeSH
- Acinetobacter drug effects pathogenicity MeSH
- Drug Resistance, Microbial MeSH
- Bacterial Adhesion drug effects MeSH
- Meropenem MeSH
- Microbial Sensitivity Tests MeSH
- Surface Properties drug effects MeSH
- Thienamycins pharmacology MeSH
- Xylenes metabolism MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Meropenem MeSH
- Thienamycins MeSH
- Xylenes MeSH
Six strains of Acinetobacter baumannii out of eleven strains tested revealed a strong hydrophobic character. This was demonstrated by adherence of bacteria to xylene in the range of 90-94%. Changes in surface hydrophobicity of these strains were studied after treatment with meropenem at subinhibitory concentrations (sub-MICs) (1/4, 1/8, 1/16 or 1/32 of the MICs). All strains showed a reduced adherence to xylene after the action of meropenem at 1/4 or 1/16 of the MICs. Hydrophobicity of the treated bacteria was decreased to 1.3-70% (1/16 of the MICs) or to 12-86% (1/4 of the MICs), depending on the strain. A decrease in surface hydrophobicity of three strains was also observed after their exposure to meropenem at 1/8 of the MICs (to 18-71% of the control values). Meropenem at 1/32 of the MICs practically did not affect bacterial hydrophobic properties, with the exception of one strain.
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