Detection of cytoskeletal proteins in small cell lung carcinoma
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
10707834
Knihovny.cz E-zdroje
- MeSH
- cytoskeletální proteiny metabolismus MeSH
- fosfopyruváthydratasa metabolismus MeSH
- imunohistochemie MeSH
- keratiny metabolismus MeSH
- lidé MeSH
- malobuněčný karcinom diagnóza metabolismus patologie MeSH
- monoklonální protilátky MeSH
- mucin 1 metabolismus MeSH
- nádorové biomarkery metabolismus MeSH
- nádory plic diagnóza metabolismus patologie MeSH
- tubulin metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cytoskeletální proteiny MeSH
- fosfopyruváthydratasa MeSH
- keratiny MeSH
- monoklonální protilátky MeSH
- mucin 1 MeSH
- nádorové biomarkery MeSH
- tubulin MeSH
Small cell lung carcinoma (SCLC) is the most aggressive of lung tumors, metastasize widely and are virtually incurable by surgical means. Therefore, the classification of lung cancer into SCLC and non-small cell lung carcinoma is essential for disease prognosis and treatment. For this purpose we have compared the immunohistochemical distribution of different cytoskeletal proteins as tumor markers. Analysis was performed by using of monoclonal antibodies directed against cytokeratins, neurofilaments, betaIII-tubulin, epithelial membrane antigen and neuron-specific enolase. Our results indicate that keratin and epithelial membrane antigen are reliable epithelial markers for SCLC. In addition, the positive staining with monoclonal antibodies TU-20 against betaIII-tubulin and neuron-specific enolase was found in some cases of SCLC. We suggest, that these antibodies could be a useful tool for complex immunohistochemical diagnosis of SCLC.
