Detection of cytoskeletal proteins in small cell lung carcinoma
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10707834
Knihovny.cz E-resources
- MeSH
- Cytoskeletal Proteins metabolism MeSH
- Phosphopyruvate Hydratase metabolism MeSH
- Immunohistochemistry MeSH
- Keratins metabolism MeSH
- Humans MeSH
- Carcinoma, Small Cell diagnosis metabolism pathology MeSH
- Antibodies, Monoclonal MeSH
- Mucin-1 metabolism MeSH
- Biomarkers, Tumor metabolism MeSH
- Lung Neoplasms diagnosis metabolism pathology MeSH
- Tubulin metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cytoskeletal Proteins MeSH
- Phosphopyruvate Hydratase MeSH
- Keratins MeSH
- Antibodies, Monoclonal MeSH
- Mucin-1 MeSH
- Biomarkers, Tumor MeSH
- Tubulin MeSH
Small cell lung carcinoma (SCLC) is the most aggressive of lung tumors, metastasize widely and are virtually incurable by surgical means. Therefore, the classification of lung cancer into SCLC and non-small cell lung carcinoma is essential for disease prognosis and treatment. For this purpose we have compared the immunohistochemical distribution of different cytoskeletal proteins as tumor markers. Analysis was performed by using of monoclonal antibodies directed against cytokeratins, neurofilaments, betaIII-tubulin, epithelial membrane antigen and neuron-specific enolase. Our results indicate that keratin and epithelial membrane antigen are reliable epithelial markers for SCLC. In addition, the positive staining with monoclonal antibodies TU-20 against betaIII-tubulin and neuron-specific enolase was found in some cases of SCLC. We suggest, that these antibodies could be a useful tool for complex immunohistochemical diagnosis of SCLC.
