Gene aberrations in childhood brain tumors
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11055797
Knihovny.cz E-resources
- MeSH
- Gene Amplification MeSH
- Aneuploidy * MeSH
- Chromosome Aberrations * MeSH
- Chromosome Deletion MeSH
- Child MeSH
- Gene Duplication MeSH
- Genes, myc MeSH
- Glioma genetics MeSH
- In Situ Hybridization, Fluorescence MeSH
- Infant MeSH
- Humans MeSH
- Chromosomes, Human, Pair 17 MeSH
- Medulloblastoma genetics MeSH
- Adolescent MeSH
- Cerebellar Neoplasms genetics MeSH
- Brain Neoplasms classification genetics MeSH
- Ploidies MeSH
- Child, Preschool MeSH
- Neuroectodermal Tumors, Primitive genetics MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
We present the results of the examination of prognostic markers in 40 children suffering from brain tumors. Prognostic markers such as amplification of the N-myc and c-myc, deletion of the 17p, and DNA ploidy are indispensable factors for the determination of diagnosis. An increased number of c-myc gene copies was found in malignant brain tumors, especially embryonal, more often than reported in the literature. N-myc amplification occurs in our group seldom, but it seems to be a sign of worse prognosis in glial and embryonal brain tumors. DNA aneuploidy was not found very frequently, but in high-grade tumors only.
Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma
