Cardiac troponin T in neonates after acute and long-term tocolysis
Language English Country Switzerland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11093008
DOI
10.1159/000014281
PII: 14281
Knihovny.cz E-resources
- MeSH
- Adrenergic beta-Agonists adverse effects MeSH
- Electrocardiography MeSH
- Fetal Blood chemistry MeSH
- Isoenzymes blood MeSH
- Cardiomyopathies chemically induced MeSH
- Creatine Kinase blood MeSH
- Humans MeSH
- Myocardium enzymology MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Tocolytic Agents adverse effects MeSH
- Tocolysis adverse effects MeSH
- Troponin T blood MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adrenergic beta-Agonists MeSH
- Isoenzymes MeSH
- Creatine Kinase MeSH
- Tocolytic Agents MeSH
- Troponin T MeSH
The present study was designed to determine the levels of cardiac troponin T (cTnT) in cord blood of neonates exposed in utero to tocolytic therapy by beta-sympathomimetics. cTnT in 40 neonates after acute tocolysis (0.24 +/- 0.05 microg/l) was significantly higher (p < 0.05) in comparison with the control group (0.05 +/- 0.01 microg/l). The maximal values were reached in about the 3rd day of therapy (0.39 +/- 0.11 microg/l). cTnT in 30 neonates after long-term tocolysis was 0.12 +/- 0.03 microg/l. No correlation was found between cTnT and CK and its isoenzyme CK-MB or ECG. CK, unlike cTnT, significantly correlated with gestational age (r = 0.57, p < 0.05) and birth weight (r = 0.55, p < 0.05). It is possible to conclude that acute tocolytic therapy by beta-sympathomimetics increases the cTnT levels in cord blood and cardiac troponin T is more useful for the laboratory diagnosis of neonatal myocardial injury than CK-MB.
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