Butylaminiperindopril decreases transforming growth factor-beta 1 messenger RNA production in lungs of C57Bl6 mice after low-dose whole-body irradiation
Language English Country Switzerland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11109510
Knihovny.cz E-resources
- MeSH
- Whole-Body Irradiation * MeSH
- Angiotensin-Converting Enzyme Inhibitors pharmacology MeSH
- Captopril pharmacology MeSH
- RNA, Messenger biosynthesis MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Perindopril analogs & derivatives pharmacology MeSH
- Lung drug effects metabolism radiation effects MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Transforming Growth Factor beta genetics MeSH
- Free Radicals MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Angiotensin-Converting Enzyme Inhibitors MeSH
- Captopril MeSH
- RNA, Messenger MeSH
- Perindopril MeSH
- Transforming Growth Factor beta MeSH
- Free Radicals MeSH
Transforming growth factor (TGF)-beta is believed to play a key role in the development of many autoimmune and malignant diseases, such as radiation and drug-induced organ disease. The aim of the present study was to determine messenger RNA (mRNA) production of TGF-beta 1 in the lungs of C57Bl6 mice after low-dose whole-body irradiation. Control (irradiated) and irradiated angiotensin-converting enzyme (ACE) inhibitor-treated animals were simultaneously examined. The ACE inhibitor group received butylaminiperindopril for 9 days after irradiation (7 Gy) at a daily dose of 0.1 mg/kg per rectum. On day 9 all mice were sacrificed and the production of mRNA TGF-beta 1 in lung tissue was determined semiquantitatively using reverse transcriptase polymerase chain reaction. In butylaminiperindopril-treated mice, a decrease in transcript of TGF-beta 1 (to 59% in comparison with controls) was observed.
