Regulation of myosin expression in developing and regenerating extrafusal and intrafusal muscle fibers with special emphasis on the role of thyroid hormones
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
11252527
Knihovny.cz E-zdroje
- MeSH
- biomechanika MeSH
- buněčná diferenciace MeSH
- hlavní histokompatibilní komplex genetika MeSH
- hormony štítné žlázy fyziologie MeSH
- kmenové buňky MeSH
- kosterní svalová vlákna cytologie metabolismus fyziologie MeSH
- lidé MeSH
- myosiny genetika MeSH
- regenerace MeSH
- regulace genové exprese * MeSH
- svaly transplantace MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- hormony štítné žlázy MeSH
- myosiny MeSH
Expression of the muscle phenotype is the result of interaction between intrinsic and extrinsic factors, the latter including innervation, mechanical influences and hormonal signals. This minireview summarizes some of the current knowledge regarding the regulation of myosin heavy chain (MHC) isoform transitions during muscle development and regeneration. It describes the role of genetic factors, neural and mechanical influences and it focuses on the contribution of thyroid hormones to the differentiation of muscle fiber phenotypes as shown by the regulation of the expression of MHC isoforms and development of myofibrillar ATPase activity. Finally, it shortly summarizes results regarding the differentiation of MHC isoforms in regenerated muscle fibers of the graft after heterochronous isotransplantation in rats with different thyroid status.
