Regulation of myosin expression in developing and regenerating extrafusal and intrafusal muscle fibers with special emphasis on the role of thyroid hormones
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
11252527
Knihovny.cz E-resources
- MeSH
- Biomechanical Phenomena MeSH
- Cell Differentiation MeSH
- Major Histocompatibility Complex genetics MeSH
- Thyroid Hormones physiology MeSH
- Stem Cells MeSH
- Muscle Fibers, Skeletal cytology metabolism physiology MeSH
- Humans MeSH
- Myosins genetics MeSH
- Regeneration MeSH
- Gene Expression Regulation * MeSH
- Muscles transplantation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Thyroid Hormones MeSH
- Myosins MeSH
Expression of the muscle phenotype is the result of interaction between intrinsic and extrinsic factors, the latter including innervation, mechanical influences and hormonal signals. This minireview summarizes some of the current knowledge regarding the regulation of myosin heavy chain (MHC) isoform transitions during muscle development and regeneration. It describes the role of genetic factors, neural and mechanical influences and it focuses on the contribution of thyroid hormones to the differentiation of muscle fiber phenotypes as shown by the regulation of the expression of MHC isoforms and development of myofibrillar ATPase activity. Finally, it shortly summarizes results regarding the differentiation of MHC isoforms in regenerated muscle fibers of the graft after heterochronous isotransplantation in rats with different thyroid status.
