Influence of methylfenpropidine on growth, sterol content and fatty acid composition of Candida albicans
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
11347252
DOI
10.1007/bf02817553
Knihovny.cz E-resources
- MeSH
- Candida albicans chemistry drug effects growth & development MeSH
- Models, Chemical MeSH
- Ergosterol biosynthesis chemistry MeSH
- Fatty Acids chemistry MeSH
- Molecular Structure MeSH
- Mutation MeSH
- Piperidines pharmacology MeSH
- Fungicides, Industrial chemistry pharmacology MeSH
- Sterols chemistry MeSH
- Dose-Response Relationship, Drug MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Ergosterol MeSH
- Fatty Acids MeSH
- methylfenpropidine MeSH Browser
- Piperidines MeSH
- Fungicides, Industrial MeSH
- Sterols MeSH
The effect of methylfenpropidine on growth, lipid contents, sterol and fatty acid composition was investigated in 5 strains of Candida albicans. The sensitivity of the strains decreased in the order: wild strains > erg+ ade nysR > ade nysR erg (defective delta (8-7)-isomerase) > ade nysR erg (defective delta 5-desaturase). The presence of the inhibitor influenced fecosterol isomerization, episterol dehydrogenation, zymosterol transmethylation, ignosterol reduction and squalene epoxidation. Methylfenpropidine also induced changes in fatty acid composition, causing a reduction of the palmitic and oleic acid content with a concomitant elevation of stearic, linoleic and linolenic acid levels. The lipid unsaturation index slightly increased. Morphological changes of wild strains were observed after the fungicide treatment.
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