Influence of methylfenpropidine on growth, sterol content and fatty acid composition of Candida albicans
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
11347252
DOI
10.1007/bf02817553
Knihovny.cz E-zdroje
- MeSH
- Candida albicans chemie účinky léků růst a vývoj MeSH
- chemické modely MeSH
- ergosterol biosyntéza chemie MeSH
- mastné kyseliny chemie MeSH
- molekulární struktura MeSH
- mutace MeSH
- piperidiny farmakologie MeSH
- průmyslové fungicidy chemie farmakologie MeSH
- steroly chemie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- ergosterol MeSH
- mastné kyseliny MeSH
- methylfenpropidine MeSH Prohlížeč
- piperidiny MeSH
- průmyslové fungicidy MeSH
- steroly MeSH
The effect of methylfenpropidine on growth, lipid contents, sterol and fatty acid composition was investigated in 5 strains of Candida albicans. The sensitivity of the strains decreased in the order: wild strains > erg+ ade nysR > ade nysR erg (defective delta (8-7)-isomerase) > ade nysR erg (defective delta 5-desaturase). The presence of the inhibitor influenced fecosterol isomerization, episterol dehydrogenation, zymosterol transmethylation, ignosterol reduction and squalene epoxidation. Methylfenpropidine also induced changes in fatty acid composition, causing a reduction of the palmitic and oleic acid content with a concomitant elevation of stearic, linoleic and linolenic acid levels. The lipid unsaturation index slightly increased. Morphological changes of wild strains were observed after the fungicide treatment.
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