Effect of peroxynitrite on dormant spores and germlings of Aspergillus fumigatus in vitro
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
11347254
DOI
10.1007/bf02817555
Knihovny.cz E-zdroje
- MeSH
- Aspergillus fumigatus účinky léků fyziologie MeSH
- aspergilóza mikrobiologie MeSH
- časové faktory MeSH
- donory oxidu dusnatého farmakologie MeSH
- dusičnany farmakologie MeSH
- kur domácí MeSH
- lidé MeSH
- oxidancia farmakologie MeSH
- spory hub účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- donory oxidu dusnatého MeSH
- dusičnany MeSH
- oxidancia MeSH
- peroxynitric acid MeSH Prohlížeč
Peroxynitrite was tested for its effects on the opportunistic pathogenic fungus Aspergillus fumigatus. It did not kill any dormant or swollen (4 h in a glucose-peptone medium) conidia in concentrations up to 6.25 mmol/L and the growth of germlings (after 6 or 9 h) was only slightly inhibited by 5 mmol/L peroxynitrite. The peroxynitrite donor SIN-1 (up to 10 mmol/L, 1 d in buffer) did not kill any conidia but inhibited their germination and growth, depending on the medium. Ten mmol/L SIN-1 in a poor medium was fungistatic and germination was stopped for 20 h. Nine strains of A. fumigatus showed resistance comparable to the model strain, while 6 Candida albicans strains were much more susceptible to both peroxynitrite and its donor. The results indicate that peroxynitrite does not contribute substantially to the antifungal activity of phagocytes against A. fumigatus.
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