Enhanced systemic and mucosal antibody responses to a model protein antigen after intranasal and intratracheal immunisation using Bacillus firmus as an adjuvant
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11348668
DOI
10.1016/s0165-2478(01)00192-4
PII: S0165-2478(01)00192-4
Knihovny.cz E-resources
- MeSH
- Adjuvants, Immunologic * MeSH
- Antigens immunology MeSH
- Administration, Intranasal MeSH
- Bacillus immunology MeSH
- Bronchoalveolar Lavage Fluid immunology MeSH
- Injections MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Ovalbumin immunology MeSH
- Antibodies, Bacterial blood MeSH
- Antibodies immunology MeSH
- Respiratory Mucosa immunology MeSH
- Immunity, Mucosal * immunology MeSH
- Intestines immunology MeSH
- Intestinal Mucosa immunology MeSH
- Trachea MeSH
- Antibody Formation MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adjuvants, Immunologic * MeSH
- Antigens MeSH
- Ovalbumin MeSH
- Antibodies, Bacterial MeSH
- Antibodies MeSH
Bacillus firmus, a non-pathogenic Gram positive (G+) bacterium of the external environment was investigated for immunomodulatory properties. It stimulated an increase in anti-ovalbumin IgG in sera, bronchoalveolar lavages and intestinal washings after both intranasal (i.n.) and intratracheal (i.t.) immunisation, and enhanced anti-ovalbumin IgA in intestinal secretions and in bronchoalveolar lavage fluid after i.n. or i.t. immunisation, respectively. The immunomodulatory effect of B. firmus on antibody formation was antigen specific.
References provided by Crossref.org
Immunomodulatory properties of subcellular fractions of a G+ bacterium, Bacillus firmus
Immunomodulatory effects of Bacillus firmus on mouse peritoneal cells in vitro
