2'C-alkoxy and 2'-C-aryloxy derivatives of N-(2-phosphonomethoxyethyl)-purines and -pyrimidines: synthesis and biological activity
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11554542
DOI
10.1081/ncn-100105244
Knihovny.cz E-resources
- MeSH
- Hydrocarbons, Acyclic chemical synthesis chemistry pharmacology MeSH
- Anticarcinogenic Agents chemical synthesis chemistry pharmacology MeSH
- Cell Line MeSH
- Chromatography, Thin Layer MeSH
- DNA Viruses drug effects MeSH
- HeLa Cells MeSH
- Mass Spectrometry MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Purines chemical synthesis chemistry pharmacology MeSH
- Pyrimidines chemical synthesis chemistry pharmacology MeSH
- Retroviridae drug effects MeSH
- Spectrophotometry, Ultraviolet MeSH
- Chromatography, High Pressure Liquid MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Hydrocarbons, Acyclic MeSH
- Anticarcinogenic Agents MeSH
- Purines MeSH
- Pyrimidines MeSH
A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship within the area of acyclic nucleotide analogues.
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