Effects of prostaglandin E2 and nitric oxide inhibitors on the expression of interleukin-10, interleukin-12 and MHC class-II molecules in Mycobacterium microti-infected and interferon-gamma-treated mouse peritoneal macrophages
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
11702410
DOI
10.1007/bf02818541
Knihovny.cz E-zdroje
- MeSH
- antitumorózní látky farmakologie MeSH
- dinoproston antagonisté a inhibitory metabolismus MeSH
- histokompatibilita - antigeny třídy II biosyntéza MeSH
- indomethacin farmakologie MeSH
- inhibitory cyklooxygenasy farmakologie MeSH
- interferon gama farmakologie MeSH
- interleukin-10 biosyntéza MeSH
- interleukin-12 biosyntéza MeSH
- mykobakteriózy imunologie metabolismus MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- omega-N-methylarginin farmakologie MeSH
- oxid dusnatý antagonisté a inhibitory metabolismus MeSH
- peritoneální makrofágy účinky léků metabolismus mikrobiologie MeSH
- teprotid farmakologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antitumorózní látky MeSH
- dinoproston MeSH
- histokompatibilita - antigeny třídy II MeSH
- indomethacin MeSH
- inhibitory cyklooxygenasy MeSH
- interferon gama MeSH
- interleukin-10 MeSH
- interleukin-12 MeSH
- omega-N-methylarginin MeSH
- oxid dusnatý MeSH
- teprotid MeSH
Mycobacterium microti-infected mouse peritoneal macrophages produced high amounts of prostaglandin E2 (PGE2) and nitric oxide (NO) when activated with interferon-gamma (IFN-gamma). In order to understand the relation between PGE2 and NO production and the expression of interleukin-12 (IL-12), interleukin-10 (IL-10) and MHC class-II (Ia) molecules by M. microti-infected and IFN-gamma-stimulated macrophages, we analyzed the level of these molecules in the presence or absence of PGE2 and NO inhibitors. Addition of NG-methyl-L-arginine (L-NMA) and indomethacin (IM) caused a significant increase in IL-12 level (2.6- and 1.9-fold, respectively) whereas IL-10 level decreased by 88 and 56%, respectively, relative to M. microti-infected and IFN-gamma-treated control macrophages. Enhanced PGE2 and NO upregulated IL-10 expression and down-regulated IL-12 and MHC class-II (Ia) expression in M. microti-infected and IFN-gamma-treated mouse peritoneal macrophages.
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