Source activity in the human secondary somatosensory cortex depends on the size of corpus callosum
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11988229
DOI
10.1016/s0006-8993(02)02502-7
PII: S0006899302025027
Knihovny.cz E-resources
- MeSH
- Afferent Pathways anatomy & histology physiology MeSH
- Corpus Callosum anatomy & histology physiology MeSH
- Adult MeSH
- Electric Stimulation MeSH
- Electroencephalography MeSH
- Functional Laterality physiology MeSH
- Touch physiology MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain Mapping MeSH
- Mechanoreceptors physiology MeSH
- Models, Neurological MeSH
- Motor Cortex anatomy & histology physiology MeSH
- Neural Conduction physiology MeSH
- Reaction Time physiology MeSH
- Evoked Potentials, Somatosensory physiology MeSH
- Somatosensory Cortex anatomy & histology physiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
If corpus callosum (CC) mediates the activation of the secondary somatosensory area (SII) ipsilateral to the side of stimulation, then the peak latencies of the contra- and ipsilateral SII activity as well as the amplitude of the ipsilateral SII activity should correlate with the size of CC. Innocuous electrical stimuli of five different intensities were applied to the ventral surface of the right index finger in 15 right-handed men. EEG was recorded using 82 closely spaced electrodes. The size of CC and of seven callosal regions was measured from the mid-sagittal slice of a high-resolution anatomical MRI. The activation in the contralateral and ipsilateral SII was evaluated using spatio-temporal source analysis. At the strongest stimulus intensity, the size of the intermediate part of the callosal truncus correlated negatively with the interpeak latency of the sources in ipsi- and contralateral SII (r = -0.83, P < 0.01). Stepwise regression analysis showed that the large size of the intermediate truncus of CC was paralleled by a latency reduction of peak activity of the ipsilateral SII, whereas both contra- and ipsilateral peak latencies were positively correlated. The peak amplitude of the ipsilateral SII source correlated positively with the size of the intermediate truncus of CC, and with the peak amplitudes of sources in the primary somatosensory cortex (SI) and in the mesial frontal cortex. The results suggest that in right-handed neurologically normal men, the size of the intermediate callosal truncus contributes to the timing and amplitude of ipsilateral SII source activity.
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