Citalopram inhibits L-type calcium channel current in rat cardiomyocytes in culture
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12234126
Knihovny.cz E-resources
- MeSH
- Citalopram pharmacology MeSH
- Myocytes, Cardiac cytology drug effects physiology MeSH
- Rats MeSH
- Cells, Cultured MeSH
- Membrane Potentials drug effects MeSH
- Patch-Clamp Techniques MeSH
- Selective Serotonin Reuptake Inhibitors pharmacology MeSH
- Calcium metabolism MeSH
- Calcium Channels, L-Type metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Citalopram MeSH
- Serotonin Uptake Inhibitors MeSH
- Calcium MeSH
- Calcium Channels, L-Type MeSH
Selective serotonine reuptake inhibitors (SSRI) are believed to be less dangerous in the treatment of depressive disorder in comparison with tricyclic antidepressants (TCA) due to their relative lack of cardiotoxicity. Thus, we investigated the effect of citalopram (SSRI) on membrane electrophysiology in rat cardiomyocytes in tissue culture. The results were compared with those from amitriptyline (TCA). The whole-cell configuration patch-clamp technique was used. Both citalopram and amitriptyline exhibited the concentration-dependent inhibition of the L-type calcium channel current (ICa). Citalopram in concentrations of 3 microM and 10 microM inhibited peak calcium current by 2.7% and 8%, respectively. We demonstrated the same potency of citalopram and amitriptyline to inhibit ICa. These observations led us to conclude that citalopram and amitriptyline are drugs, which exhibit a similar potency for causing concentration-dependent inhibition of ICa.
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