Molecular aspects of resistance to antitumor platinum drugs
Jazyk angličtina Země Scotland Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
12237082
DOI
10.1016/s1368-7646(02)00047-x
PII: S136876460200047X
Knihovny.cz E-zdroje
- MeSH
- adukty DNA účinky léků MeSH
- chemorezistence genetika MeSH
- cisplatina terapeutické užití MeSH
- lidé MeSH
- molekulární biologie metody MeSH
- oprava DNA účinky léků MeSH
- organoplatinové sloučeniny terapeutické užití MeSH
- oxaliplatin MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- adukty DNA MeSH
- BBR 3464 MeSH Prohlížeč
- cisplatina MeSH
- organoplatinové sloučeniny MeSH
- oxaliplatin MeSH
The processes by which cells develop resistance to antitumor platinum drugs have been the subject of intense research because resistance is a major obstacle for the clinical use of this class of drugs. It is therefore of great interest to understand the molecular and biochemical mechanisms that underlie resistance to platinum drugs and their biological effects. There is a large body of experimental evidence suggesting that the antitumor activity of platinum complexes stems from their ability to form on DNA various types of covalent adducts. As a result, research on DNA modifications by these drugs and their cellular processing has predominated. The resistance of tumor cells to platinum drugs has been attributed to several processes and an increased repair of platinum-DNA adducts is considered a most significant event. The present review summarizes recent insights into the effects of sulfur-containing compounds on DNA modifications by antitumor platinum complexes and how these modifications are repaired including how this repair is associated with their recognition by cellular, damaged-DNA binding-proteins. It strongly supports the view that changes in the structure of platinum drugs, resulting in DNA binding mode fundamentally different from that of "classical" cisplatin, will alter resistance pathways of platinum drugs, and may also modulate their pharmacological properties.
Citace poskytuje Crossref.org
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