Antimicrobial activity of berberine--a constituent of Mahonia aquifolium
Language English Country United States Media print
Document type Journal Article
PubMed
12422513
DOI
10.1007/bf02818693
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents MeSH
- Drug Resistance, Microbial MeSH
- Antifungal Agents isolation & purification pharmacology MeSH
- Anti-Infective Agents isolation & purification pharmacology MeSH
- Berberine isolation & purification pharmacology MeSH
- Gram-Negative Bacteria drug effects MeSH
- Gram-Positive Bacteria drug effects MeSH
- Fungi drug effects MeSH
- Yeasts drug effects MeSH
- Mahonia chemistry MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Antifungal Agents MeSH
- Anti-Infective Agents MeSH
- Berberine MeSH
The antimicrobial activity of the protoberberine alkaloid, berberine, isolated from Mahonia aquifolium, was evaluated against 17 microorganisms including two Gram-negative bacteria--Pseudomonas aeruginosa and Escherichia coli (both resistant and sensitive), two Gram-positive bacteria--Bacillus subtilis and Staphylococcus aureus, Zoogloea ramigera, six filamentous fungi--Penicilium chrysogenum, Aspergillus niger, Aureobasidium pullulans (black and white strain), Trichoderma viride (original green strain and brown mutant), Fusarium nivale, Mycrosporum gypseum and two yeasts--Candida albicans and Saccharomyces cerevisiae. The IC50, minimum inhibitory concentration (MIC), minimum microbicidal concentration (MMC) and minimum microbistatic concentration (MMS) varied considerably depending on the microorganism tested, the sensitivity decreasing as follows: S. aureus > P. aeruginosa S (sensitive) > E. coli S > P. aeruginosa R (resistant) > E. coli R > B. subtilis > Z. ramigera > C. albicans > S. cerevisiae > A. pullulans B (black) > A. pullulans W (white) > T. viride Br (brown) > M. gypseum > A. niger > F. nivale > P. chrysogenum > T. viride G (green).
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