Trehalose, glycogen and ethanol metabolism in the gcr1 mutant of Saccharomyces cerevisiae
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12800502
DOI
10.1007/bf02930955
Knihovny.cz E-zdroje
- MeSH
- DNA vazebné proteiny genetika metabolismus MeSH
- ethanol metabolismus MeSH
- fungální proteiny genetika metabolismus MeSH
- glykogen metabolismus MeSH
- kultivační média MeSH
- mutace * MeSH
- regulace genové exprese u hub MeSH
- Saccharomyces cerevisiae - proteiny MeSH
- Saccharomyces cerevisiae genetika růst a vývoj metabolismus MeSH
- transkripční faktory MeSH
- trehalosa metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- DNA vazebné proteiny MeSH
- ethanol MeSH
- fungální proteiny MeSH
- GCR1 protein, S cerevisiae MeSH Prohlížeč
- glykogen MeSH
- kultivační média MeSH
- Saccharomyces cerevisiae - proteiny MeSH
- transkripční faktory MeSH
- trehalosa MeSH
Since Gcr1p is pivotal in controlling the transcription of glycolytic enzymes and trehalose metabolism seems to be one of the control points of glycolysis, we examined trehalose and glycogen synthesis in response to 2% glucose pulse during batch growth in gcr1 (glucose regulation-1) mutant lacking fully functional glycolytic pathway and in the wild-type strain. An increase in both trehalose and glycogen stores was observed 1 and 2 h after the pulse followed by a steady decrease in both the wild-type and the gcr1 mutant. The accumulation was faster while the following degradation was slower in gcr1 cells compared to wild-type ones. Although there was no distinct glucose consumption in the mutant cells it seemed that the glucose repression mechanism is similar in gcr1 mutant and in wild-type strain at least with respect to trehalose and glycogen metabolism.
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