Trehalose, glycogen and ethanol metabolism in the gcr1 mutant of Saccharomyces cerevisiae
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12800502
DOI
10.1007/bf02930955
Knihovny.cz E-resources
- MeSH
- DNA-Binding Proteins genetics metabolism MeSH
- Ethanol metabolism MeSH
- Fungal Proteins genetics metabolism MeSH
- Glycogen metabolism MeSH
- Culture Media MeSH
- Mutation * MeSH
- Gene Expression Regulation, Fungal MeSH
- Saccharomyces cerevisiae Proteins MeSH
- Saccharomyces cerevisiae genetics growth & development metabolism MeSH
- Transcription Factors MeSH
- Trehalose metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA-Binding Proteins MeSH
- Ethanol MeSH
- Fungal Proteins MeSH
- GCR1 protein, S cerevisiae MeSH Browser
- Glycogen MeSH
- Culture Media MeSH
- Saccharomyces cerevisiae Proteins MeSH
- Transcription Factors MeSH
- Trehalose MeSH
Since Gcr1p is pivotal in controlling the transcription of glycolytic enzymes and trehalose metabolism seems to be one of the control points of glycolysis, we examined trehalose and glycogen synthesis in response to 2% glucose pulse during batch growth in gcr1 (glucose regulation-1) mutant lacking fully functional glycolytic pathway and in the wild-type strain. An increase in both trehalose and glycogen stores was observed 1 and 2 h after the pulse followed by a steady decrease in both the wild-type and the gcr1 mutant. The accumulation was faster while the following degradation was slower in gcr1 cells compared to wild-type ones. Although there was no distinct glucose consumption in the mutant cells it seemed that the glucose repression mechanism is similar in gcr1 mutant and in wild-type strain at least with respect to trehalose and glycogen metabolism.
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