Search for protein partners of mitochondrial single-stranded DNA-binding protein Rim1p using a yeast two-hybrid system
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, P.H.S.
Grantová podpora
1-R03-TW05654-01
FIC NIH HHS - United States
PubMed
12807077
DOI
10.1007/bf02930953
Knihovny.cz E-zdroje
- MeSH
- DNA vazebné proteiny metabolismus MeSH
- fungální proteiny metabolismus MeSH
- jednovláknová DNA metabolismus MeSH
- mitochondriální DNA metabolismus MeSH
- represorové proteiny MeSH
- Saccharomyces cerevisiae - proteiny metabolismus MeSH
- Saccharomyces cerevisiae genetika metabolismus MeSH
- techniky dvojhybridového systému * MeSH
- transkripční faktory metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Názvy látek
- AZF1 protein, S cerevisiae MeSH Prohlížeč
- DNA vazebné proteiny MeSH
- fungální proteiny MeSH
- jednovláknová DNA MeSH
- mitochondriální DNA MeSH
- represorové proteiny MeSH
- RIM101 protein, S cerevisiae MeSH Prohlížeč
- Saccharomyces cerevisiae - proteiny MeSH
- transkripční faktory MeSH
RIM1 is a nuclear gene of the yeast Saccharomyces cerevisiae coding for a protein with single-stranded DNA-binding activity that is essential for mitochondrial genome maintenance. No protein partners of Rim1p have been described so far in yeast. To better understand the role of this protein in mitochondrial DNA replication and recombination, a search for protein interactors by the yeast two-hybrid system was performed. This approach led to the identification of several candidates, including a putative transcription factor, Azf1p, and Mph1p, a protein with an RNA helicase domain which is known to influence the mutation rate of nuclear and mitochondrial genomes.
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
