The aim was to study the blood-brain permeability according to the distribution in the rat brain of Evans blue (EB) and sodium fluorescein (NaFl) administered by an intracarotid injection. Eighteen animals were divided into six groups according to the state of the blood-brain barrier (BBB) at the moment when the dyes were being applied. In the first two groups, the BBB was intact, in groups 3 and 4 the barrier had been opened osmotically prior to the application of the dyes, and in groups 5 and 6 a cellular edema was induced by hyperhydration before administration of the dyes. The intracellular and extracellular distribution of the dyes was studied by fluorescence microscopy. The histological picture thus represented the morphological correlate of the way BBB permeability had been changed before the application of the dyes.

Neurosurgical Clinic Central Military Hospital U vojenské nemocnice 1200 169 02 Prague 6 Czech Republic

Assessment of Blood-Brain Barrier Permeability in a Cerebral Ischemia-Reperfusion Model in Rats; A Pilot Study

Cerebral perfusion pressure and behavior monitoring in freely moving rats

Effect of methylprednisolone on experimental brain edema in rats - own experience reviewed

Effect of methylprednisolone on experimental brain edema in magnetic resonance imaging