Effect of methylprednisolone on experimental brain edema in magnetic resonance imaging
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
32901489
PubMed Central
PMC8549911
DOI
10.33549/physiolres.934460
PII: 934460
Knihovny.cz E-zdroje
- MeSH
- antiflogistika farmakologie MeSH
- edém mozku diagnostické zobrazování farmakoterapie patologie MeSH
- hipokampus diagnostické zobrazování účinky léků MeSH
- krysa rodu Rattus MeSH
- magnetická rezonanční tomografie metody MeSH
- methylprednisolon farmakologie MeSH
- modely nemocí na zvířatech MeSH
- mozek diagnostické zobrazování účinky léků MeSH
- mozková kůra diagnostické zobrazování účinky léků MeSH
- potkani Wistar MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiflogistika MeSH
- methylprednisolon MeSH
Magnetic resonance imaging has been used for evaluating of a brain edema in experimental animals to assess cytotoxic and vasogenic edema by the apparent diffusion coefficient (ADC) and T2 imaging. This paper brings information about the effectiveness of methylprednisolone (MP) on experimental brain edema. A total of 24 rats were divided into three groups of 8 animals each. Rats with cytotoxic/intracellular brain edema induced by water intoxication were assigned to the group WI. These rats also served as the additional control group CG when measured before the induction of edema. A third group (WIMP) was intraperitoneally administered with methylprednisolone 100 mg/kg during water intoxication treatment. The group WI+MP was injected with methylprednisolone 50 mg/kg into the carotid artery within two hours after the water intoxication treatment. We evaluated the results in four groups. Two control groups (CG, WI) and two experimental groups (WIMP, WI+MP). Rats were subjected to MR scanning 24 h after edema induction. We observed significantly increased ADC values in group WI in both evaluated areas - cortex and hippocampus, which proved the occurrence of experimental vasogenic edema, while ADC values in groups WIMP and WI+MP were not increased, indicating that the experimental edema was not developed and thus confirming the protective effect of MP.
Zobrazit více v PubMed
AYATA C, ROPPER AH. Ischaemic brain oedema. J Clin Neurosci. 2002;9:113–124. doi: 10.1054/jocn.2001.1031. PubMed DOI
BADAUT J, ASHWAL S, TONE B, REGLI L, TIAN HR, OBENAUS A. Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke. Pediatr Res. 2007;62:248–254. doi: 10.1203/pdr.0b013e3180db291b. PubMed DOI
BATTEY TW, KARKI M, SINGHAL AB, WU O, SADAGHIANI S, CAMPBELL BC, DAVIS SM, DONNAN GA, SHETH KN, KIMBERLY WT. Brain edema predicts outcome after nonlacunar ischemic stroke. Stroke. 2014;45:3643–3648. doi: 10.1161/strokeaha.114.006884. PubMed DOI PMC
BULLOCK MR, LYETH BG, MUIZELAAR JP. Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies. Neurosurgery. 1999;45:207–220. doi: 10.1097/00006123-199908000-00001. PubMed DOI
FADEN AI, SALZMAN S. Pharmacological strategies in CNS trauma. Trends Pharmacol Sci. 1992;13:29–35. doi: 10.1016/0165-6147(92)90013-v. PubMed DOI
HALL ED. The neuroprotective pharmacology of methylprednisolone. J Neurosurg. 1992;76:13–22. doi: 10.3171/jns.1992.76.1.0013. PubMed DOI
HALL ED. The role of oxygen radicals in traumatic injury: clinical implications. J Emerg Med. 1993;11(Suppl 1):31–36. PubMed
HERYNEK V, WAGNEROVÁ D, HEJLOVÁ I, DEZORTOVÁ M, HÁJEK M. Changes in the brain during long-term follow-up after liver transplantation. J Magn Reson Imaging. 2012;35:1332–1337. doi: 10.1002/jmri.23599. PubMed DOI
ITO J, MARMAROU A, BARZÓ P, FATOUROS P, CROWIN F. Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury. J Neurosurg. 1996;84:97–103. doi: 10.3171/jns.1996.84.1.0097. PubMed DOI
KOZLER P, POKORNÝ J. Altered blood-brain barrier permeability and its effect on the distribution of Evans blue and sodium fluorescein in the rat brain applied by intracarotid injection. Physiol Res. 2003;52:607–614. PubMed
KOZLER P, POKORNÝ J. Effects of intracarotid injection of methylprednisolone on cellular oedema after osmotic opening of the blood-brain barrier in rats. Prague Med Rep. 2004;105:279–290. PubMed
KOZLER P, RILJAK V, POKORNÝ J. Methylprednisolone reduces axonal impairment in the experimental model of brain oedema. Neuro Endocrinol Lett. 2011;32:831–835. PubMed
KOZLER P, POKORNY J. Effect of methylprednisolone on the axonal impairment accompanying cellular brain oedema induced by water intoxication in rats. Neuro Endocrinol Lett. 2012;33:782–786. PubMed
KOZLER P, RILJAK V, POKORNÝ J. Both water intoxication and osmotic BBB disruption increase brain water content in rats. Physiol Res. 2013;62(Suppl 1):S75–S80. doi: 10.33549/physiolres.932566. PubMed DOI
KOZLER P, RILJAK V, JANDOVÁ K, POKORNÝ J. CT imaging and spontaneous behavior analysis after osmotic blood-brain barrier opening in Wistar rat. Physiol Res. 2014;63(Suppl 4):S529–S534. doi: 10.33549/physiolres.932935. PubMed DOI
KOZLER P, POKORNY J. CT density decrease in water intoxication rat model of brain oedema. Neuro Endocrinol Lett. 2014;35:608–612. PubMed
KOZLER P, SOBEK O, POKORNÝ J. Signs of myelin impairment in cerebrospinal fluid after osmotic opening of the blood-brain barrier in rats. Physiol Res. 2015;64(Suppl 5):S603–S608. doi: 10.33549/physiolres.933220. PubMed DOI
KOZLER P, MAREŠOVÁ D, POKORNÝ J. Methylprednisolone modulates intracranial pressure in the brain cellular edema induced by water intoxication. Physiol Res. 2017;66(Suppl 4):S511–S516. doi: 10.33549/physiolres.933797. PubMed DOI
KOZLER P, MARESOVA D, POKORNY J. Cellular brain edema induced by water intoxication in rat experimental model. Neuro Endocrinol Lett. 2018;39:209–218. PubMed
KROLL RA, NEUWELT EA. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery. 1998;42:1083–1100. doi: 10.1097/00006123-199805000-00086. PubMed DOI
LIANG D, BHATTA S, GERZANICH V, SIMARD JM. Cytotoxic edema: mechanisms of pathological cell swelling. Neurosurg Focus. 2007;22:E2. doi: 10.3171/foc.2007.22.5.3. PubMed DOI PMC
LOUBINOUX I, VOLK A, BORREDON J, GUIRIMAND S, TIFFON B, SEYLAZ J, MÉRIC P. Spreading of vasogenic edema and cytotoxic edema assessed by quantitative diffusion and T2 magnetic resonance imaging. Stroke. 1997;28:419–426. doi: 10.1161/01.str.28.2.419. PubMed DOI
LYTHGOE MF, THOMAS DL, CALAMANTE F, PELL GS, KING MD, BUSZA AL, SOTAK CH, WILLIAMS SR, ORDIDGE RJ, GADIAN DG. Acute changes in MRI diffusion, perfusion, T(1), and T(2) in a rat model of oligemia produced by partial occlusion of the middle cerebral artery. Magn Reson Med. 2000;44:706–712. doi: 10.1002/1522-2594(200011)44:5<706::aid-mrm8>3.0.co;2-1. PubMed DOI
MANLEY GT, FUJIMURA M, MA T, NOSHITA N, FILIZ F, BOLLEN AW, CHAN P, VERKMAN AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000;6:159–163. doi: 10.1038/72256. PubMed DOI
MARMAROU A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus. 2007;22:E1. doi: 10.3171/foc.2007.22.5.2. PubMed DOI
MICHINAGA S, KOYAMA Y. Pathogenesis of brain edema and investigation into anti-edema drugs. Int J Mol Sci. 2015;16:9949–9975. doi: 10.3390/ijms16059949. PubMed DOI PMC
PARK CO. The effects of methylprednisolone on prevention of brain edema after experimental moderate diffuse brain injury in rats: comparison between dosage, injection time, and treatment methods. Yonsei Med J. 1998;39:395–403. doi: 10.3349/ymj.1998.39.5.395. PubMed DOI
RAPOPORT SI. Effect of concentrated solutions on blood-brain barrier. Am J Physiol. 1970;219:270–274. doi: 10.1152/ajplegacy.1970.219.1.270. PubMed DOI
RAPOPORT SI. Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cell Mol Neurobiol. 2000;20:217–230. doi: 10.1023/a:1007049806660. PubMed DOI PMC
REULEN HJ. Bulk flow and diffusion revisited, and clinical applications. Acta Neurochir (Suppl) 2010;106:3–13. doi: 10.1007/978-3-211-98811-4_1. PubMed DOI
SIMARD JM, KENT TA, CHEN M, TARASOV KV, GERZANICH V. Brain oedema in focal ischaemia: Molecular pathophysiology and theoretical implications. Lancet Neurol. 2007;6:258–268. doi: 10.1016/s1474-4422(07)70055-8. PubMed DOI PMC
SLIVKA PA, MURPHY EJ. High-dose methylprednisolone treatment in experimental focal cerebral ischemia. Exp Neurol. 2001;167:166–172. doi: 10.1006/exnr.2000.7532. PubMed DOI
SORBY-ADAMS AJ, MARCOIONNI AM, DEMPSEY ER, WOENIG JA, TURNER RJ. The role of neurogenic inflammation in blood-brain barrier disruption and development of cerebral oedema following acute central nervous system (CNS) injury. Int J Mol Sci. 2017;18:E1788. doi: 10.3390/ijms18081788. PubMed DOI PMC
STUMMER W. Mechanisms of tumor-related brain edema. Neurosurg Focus. 2007;22:E8. doi: 10.3171/foc.2007.22.5.9. PubMed DOI
WAGNEROVÁ D, HERYNEK V, MALUCELLI A, DEZORTOVÁ M, VYMAZAL J, URGOŠÍK D, SYRŮČEK M, JIRU F, SKOCH A, BARTOŠ R, SAMEŠ M, HAJEK M. Quantitative MR imaging and spectroscopy of brain tumours: a step forward? Eur Radiol. 2012;22:2307–2318. doi: 10.1007/s00330-012-2502-6. PubMed DOI
XU M, SU W, XU QP. Aquaporin-4 and traumatic brain edema. Chin J Traumatol. 2010;13:103–110. PubMed
YANG B, ZADOR Z, VERKMAN AS. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J Biol Chem. 2008;22:15280–15286. doi: 10.1074/jbc.m801425200. PubMed DOI PMC
Cerebral perfusion pressure and behavior monitoring in freely moving rats
Effect of methylprednisolone on experimental brain edema in rats - own experience reviewed