Immunomodulatory cytokines in human seminal plasma correlate with immunomodulatory steroids
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
14625004
DOI
10.1016/s0039-128x(03)00114-4
PII: S0039128X03001144
Knihovny.cz E-zdroje
- MeSH
- androgeny analýza MeSH
- cytokiny analýza MeSH
- dehydroepiandrosteron analýza MeSH
- dospělí MeSH
- ELISA MeSH
- estradiol analýza MeSH
- hydrokortison analýza MeSH
- interferon gama analýza MeSH
- interleukiny analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- sperma cytologie metabolismus MeSH
- steroidy analýza MeSH
- testosteron analýza MeSH
- Th1 buňky metabolismus MeSH
- Th2 buňky metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- androgeny MeSH
- cytokiny MeSH
- dehydroepiandrosteron MeSH
- estradiol MeSH
- hydrokortison MeSH
- interferon gama MeSH
- interleukiny MeSH
- steroidy MeSH
- testosteron MeSH
7alpha-Hydroxy-dehydroepiandrosterone and its 7beta-hydroxyepimer, which act as local immunomodulatory agents, dehydroepiandrosterone, cortisol, and major androgens, together with four cytokines-interleukins 2, 4, 10, and IFN-gamma, reflecting the activity of TH1 or TH2 cells present in semen, were measured in seminal plasma from 35 male donors. Cortisol, dehydroepiandrosterone, its sulfate, 7-hydroxy-dehydroepiandrosterone epimers, testosterone, and estradiol were also measured in their blood serum. Steroids and interleukins in semen as well as serum steroids and seminal interleukins were mutually correlated to find out whether a relationship between immunomodulatory steroids and cytokines influencing the immune environment does exist. A highly significant (P<0.001) positive correlation was found between seminal 7beta-hydroxy-dehydroepiandrosterone and IFN-gamma, while a negative correlation was found between cortisol and IL-10. Highly significant positive correlations were also found between serum 7alpha-hydroxy-dehydroepiandrosterone and seminal IFN-gamma and between serum 7beta-hydroxy-dehydroepiandrosterone and seminal IL-2, while a negative correlation was found between serum dehydroepiandrosterone and seminal IL-10. Different and in some instances, even contradictory findings concerning the influence of dehydroepiandrosterone and cortisol on TH1 and TH2 cytokines were observed in seminal plasma as compared to those found by others in serum. The differences can be ascribed to the different environments of mucosal and systemic immunity. Correlations between the levels of steroids and cytokines in seminal plasma did not always correspond to the correlations between given cytokines and hormones in sera. The results, however, are in agreement with our recent finding of an autonomous production of these steroids in the male reproductive tract.
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