Long-term changes of activity of cortical neurons after status epilepticus induced at early developmental stages in rats
Language English Country Ireland Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
14625039
DOI
10.1016/j.neulet.2003.08.043
PII: S030439400301036X
Knihovny.cz E-resources
- MeSH
- Time MeSH
- Electroencephalography methods MeSH
- Rats MeSH
- Cerebral Cortex growth & development physiopathology MeSH
- Neurons physiology MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Status Epilepticus physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
Spontaneous activity of cortical neurons was studied under urethane anesthesia in adult rats 3 months after convulsive status epilepticus induced by lithium-pilocarpine administration at the age of 12 (SE12 group) or 25 (SE25 group) days. Whereas random firing neurons dominated in control animals (61 out of 98 cells), SE25 animals exhibited a significant increase in the incidence of bursting cells (38 out of 59 units). Similar change in SE12 animals did not reach the level of statistical significance. Status epilepticus at an early developmental stage may result in a long-lasting change in functions of surviving cortical neurons.
References provided by Crossref.org
