Activity of thrombocytes as a marker of sufficient intensity of LDL-apheresis in familial hypercholesterolaemia
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15062743
DOI
10.1016/j.transci.2003.11.002
PII: S1473-0502(04)00016-3
Knihovny.cz E-resources
- MeSH
- Adenosine Diphosphate chemistry MeSH
- Platelet Aggregation MeSH
- Platelet Activation MeSH
- Time Factors MeSH
- Cholesterol metabolism MeSH
- Heterozygote MeSH
- Homozygote MeSH
- Hyperlipoproteinemia Type II metabolism MeSH
- Cholesterol, LDL metabolism MeSH
- Humans MeSH
- Lipoproteins, LDL metabolism MeSH
- Receptors, LDL metabolism MeSH
- Blood Component Removal MeSH
- Blood Platelets metabolism MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine Diphosphate MeSH
- Cholesterol MeSH
- Cholesterol, LDL MeSH
- Lipoproteins, LDL MeSH
- Receptors, LDL MeSH
Extracorporal elimination is used for selective removal of LDL-cholesterol in severe hypercholesterolaemias. Tests are still going on to find more reliable markers which would sufficiently determine the intensity of the therapy immediately after completion of the procedure, in order to attenuate atherosclerosis activity. According to some literature data such a marker may be platelet aggregability. However, this marker carried out by standard methods has shown to be unreliable. The method was modified (by using various ADP dilutions for aggregation stimulation) and only then changes in aggregation could be observed immediately after completion of the procedure, namely, if there is a rapid drop in cholesterol concentration (of 6 mmol/l or more). Presently, this modification seems to be a suitable marker to determine the intensity of therapy.
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