High prevalence of coeliac disease in siblings of children with type 1 diabetes
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- biopsie MeSH
- celiakie komplikace genetika imunologie MeSH
- diabetes mellitus 1. typu komplikace MeSH
- dítě MeSH
- dospělí MeSH
- HLA-DQ alfa řetězec MeSH
- HLA-DQ antigeny analýza MeSH
- HLA-DQ beta řetězec MeSH
- imunoglobulin A krev MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- prevalence MeSH
- protilátky anti-idiotypické krev MeSH
- sourozenci * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- HLA-DQ alfa řetězec MeSH
- HLA-DQ antigeny MeSH
- HLA-DQ beta řetězec MeSH
- HLA-DQA1 antigen MeSH Prohlížeč
- HLA-DQB1 antigen MeSH Prohlížeč
- imunoglobulin A MeSH
- protilátky anti-idiotypické MeSH
UNLABELLED: Coeliac disease has been shown to occur more frequently among first-degree relatives of diabetic patients than in the general population. Our objective was to assess the prevalence of endomysium antibodies (EMA) in non-diabetic siblings of Czech diabetic children and to evaluate the effects of HLA-DQ polymorphisms in determining the genetic susceptibility to coeliac disease (CD) in these subjects. We investigated 240 siblings of diabetic children from 213 families (125 males and 115 females, aged 12.6+/-4.9 years, mean +/- SD). All subjects were tested for the total IgA level to exclude IgA deficiency, and for endomysium IgA to disclose CD. In five IgA-deficient subjects, anti-gliadin IgG was used instead. Small bowel biopsy was offered to subjects with confirmed positive EMA. The HLA-DQA1, -DQB1 genotypes were determined using PCR-SSP. Positive EMA were found in 9/240 (3.8%) subjects (three males, six females). The biopsy confirmed CD in six children, two had a normal mucosal finding and one refused the biopsy. The HLA-DQ2 polymorphism was more frequent among siblings with EMA (seven of nine) than in siblings without EMA (33%), corrected P = 0.031. CONCLUSION: The 3.8% frequency of coeliac disease found in siblings of diabetic children is close to the 4.3% found previously in Czech children with type 1 diabetes mellitus and is substantially higher than the rate in the healthy children population.
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