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PubMed

Záznam pochází z PubMed

The serologic screening for celiac disease in the general population (blood donors) and in some high-risk groups of adults (patients with autoimmune diseases, osteoporosis and infertility) in the Czech republic

Folia microbiologica. 2002 ; 47 (6) : 753-8.

Folia Microbiol (Praha)
ISSN 0015-5632
Zdroj

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid12630332

PubMed 12630332
DOI 10.1007/bf02818684
Knihovny.cz E-zdroje

MeSH
autoimunitní nemoci komplikace MeSH
celiakie komplikace diagnóza epidemiologie imunologie MeSH
dospělí MeSH
ELISA MeSH
gama-glutamyltransferasa imunologie MeSH
gliadin imunologie MeSH
imunoglobulin A krev MeSH
imunoglobulin G krev MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
osteoporóza komplikace MeSH
senioři nad 80 let MeSH
senioři MeSH
séroepidemiologické studie MeSH
ženská infertilita komplikace MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Geografické názvy
Česká republika epidemiologie MeSH
Názvy látek
gama-glutamyltransferasa MeSH
gliadin MeSH
imunoglobulin A MeSH
imunoglobulin G MeSH

The prevalence of celiac disease (CD) was determined in healthy blood donors and in high-risk groups of adults (a total of 1835 adults--randomly selected 1312 healthy blood donors, 102 patients with primary osteoporosis, 58 patients with autoimmune diseases and 365 infertile women). It was calculated on the basis of a two-step serologic screening method--in the first step IgA and IgG antigliadin antibodies (AGA) and IgA anti-gamma-glutamyltransferase ('transglutaminase') antibodies (ATG) were estimated, in the second step sera positive for IgA AGA and/or IgA ATG were examined for antiendomysial IgA (AEA) antibodies. Immunoenzymic assay (ELISA) was used for determining of AGA and ATG antibodies; immunofluorescence method, performed on human umbilical cord tissue, was used for assaying of AEA antibodies. Total serum IgA level in only IgG AGA positive subjects was measured by routine turbidimetric method. 0.45% of healthy blood donors, 0.98% of osteoporotic patients, 2.7% of patients suffering from autoimmune disease and 1.13% of women with infertility considered as immunologically mediated were found to be positive in both steps of serologic screening (AGA and/or ATG and antiendomysium positive). The presumed high prevalence of seropositivity for CD in apparently healthy Czech adult population was confirmed. In the high-risk groups, the prevalence of seropositivity for CD was approximately 2-4 times higher than in healthy blood donors. The real prevalence of CD in the tested groups, however, can be estimated after performing small intestinal biopsy in the seropositive patients.

1st Department of Pediatrics University Hospital Motol Prague Czechia

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