The prevalence of coeliac disease in Libyan children with type 1 diabetes mellitus
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12592646
DOI
10.1002/dmrr.333
Knihovny.cz E-zdroje
- MeSH
- biopsie MeSH
- celiakie komplikace epidemiologie imunologie MeSH
- diabetes mellitus 1. typu komplikace epidemiologie imunologie MeSH
- dítě MeSH
- dospělí MeSH
- gliadin imunologie MeSH
- imunoglobulin A krev MeSH
- imunoglobulin G krev MeSH
- kalretikulin imunologie MeSH
- kohortové studie MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- prevalence MeSH
- střevní sliznice imunologie patologie MeSH
- transglutaminasy imunologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Libye epidemiologie MeSH
- Názvy látek
- gliadin MeSH
- imunoglobulin A MeSH
- imunoglobulin G MeSH
- kalretikulin MeSH
- transglutaminasy MeSH
BACKGROUND: Diagnosis of atypical and silent forms of coeliac disease (CD) is important because of its serious complications. Increased prevalence of coeliac disease worldwide in individuals with type 1 diabetes mellitus (DM) was described. There are no data on the prevalence of CD in the Libyan population and Libyan DM patients. The aim of this study was to test the occurrence of CD-related markers in a group of Libyan children with DM. METHODS: A cohort of 234 Libyan children with DM (121 males and 113 females) aged between 2 and 25 years and 50 healthy school children were screened for CD using the enzyme-linked immunosorbent assay (ELISA) for IgA and IgG antigliadin (AGA), anti-tissue transglutaminase (tTG), and anticalreticulin antibodies. An IgA antiendomysial antibody (EmA) was determined by immunofluorescence. RESULTS: Fifty patients (21.3%) were positive for IgA- and/or IgG-AGA, tTG, and anticalreticulin antibodies. Nineteen of these patients were EmA positive and seven were EmA negative. From the EmA negative patients we found that five sera with IgA deficiency had high IgG class in antigliadin, anti-tissue transglutaminase, and anticalreticulin antibodies. All these patients underwent intestinal biopsy. Twenty-four had clear histological (atrophy) evidence of CD including the EmA negative patients with IgA deficiency; prevalence of CD in this study was thus 10.3%. CONCLUSION: The prevalence of CD in diabetic children in Libya was found to be higher than in several European countries. Serological markers are useful for identifying DM patients who should undergo a small intestinal biopsy.
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