The prevalence of coeliac disease in Libyan children with type 1 diabetes mellitus
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12592646
DOI
10.1002/dmrr.333
Knihovny.cz E-resources
- MeSH
- Biopsy MeSH
- Celiac Disease complications epidemiology immunology MeSH
- Diabetes Mellitus, Type 1 complications epidemiology immunology MeSH
- Child MeSH
- Adult MeSH
- Gliadin immunology MeSH
- Immunoglobulin A blood MeSH
- Immunoglobulin G blood MeSH
- Calreticulin immunology MeSH
- Cohort Studies MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- Intestinal Mucosa immunology pathology MeSH
- Transglutaminases immunology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Libya epidemiology MeSH
- Names of Substances
- Gliadin MeSH
- Immunoglobulin A MeSH
- Immunoglobulin G MeSH
- Calreticulin MeSH
- Transglutaminases MeSH
BACKGROUND: Diagnosis of atypical and silent forms of coeliac disease (CD) is important because of its serious complications. Increased prevalence of coeliac disease worldwide in individuals with type 1 diabetes mellitus (DM) was described. There are no data on the prevalence of CD in the Libyan population and Libyan DM patients. The aim of this study was to test the occurrence of CD-related markers in a group of Libyan children with DM. METHODS: A cohort of 234 Libyan children with DM (121 males and 113 females) aged between 2 and 25 years and 50 healthy school children were screened for CD using the enzyme-linked immunosorbent assay (ELISA) for IgA and IgG antigliadin (AGA), anti-tissue transglutaminase (tTG), and anticalreticulin antibodies. An IgA antiendomysial antibody (EmA) was determined by immunofluorescence. RESULTS: Fifty patients (21.3%) were positive for IgA- and/or IgG-AGA, tTG, and anticalreticulin antibodies. Nineteen of these patients were EmA positive and seven were EmA negative. From the EmA negative patients we found that five sera with IgA deficiency had high IgG class in antigliadin, anti-tissue transglutaminase, and anticalreticulin antibodies. All these patients underwent intestinal biopsy. Twenty-four had clear histological (atrophy) evidence of CD including the EmA negative patients with IgA deficiency; prevalence of CD in this study was thus 10.3%. CONCLUSION: The prevalence of CD in diabetic children in Libya was found to be higher than in several European countries. Serological markers are useful for identifying DM patients who should undergo a small intestinal biopsy.
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