High prevalence of coeliac disease in siblings of children with type 1 diabetes
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biopsy MeSH
- Celiac Disease complications genetics immunology MeSH
- Diabetes Mellitus, Type 1 complications MeSH
- Child MeSH
- Adult MeSH
- HLA-DQ alpha-Chains MeSH
- HLA-DQ Antigens analysis MeSH
- HLA-DQ beta-Chains MeSH
- Immunoglobulin A blood MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- Antibodies, Anti-Idiotypic blood MeSH
- Siblings * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- HLA-DQ alpha-Chains MeSH
- HLA-DQ Antigens MeSH
- HLA-DQ beta-Chains MeSH
- HLA-DQA1 antigen MeSH Browser
- HLA-DQB1 antigen MeSH Browser
- Immunoglobulin A MeSH
- Antibodies, Anti-Idiotypic MeSH
UNLABELLED: Coeliac disease has been shown to occur more frequently among first-degree relatives of diabetic patients than in the general population. Our objective was to assess the prevalence of endomysium antibodies (EMA) in non-diabetic siblings of Czech diabetic children and to evaluate the effects of HLA-DQ polymorphisms in determining the genetic susceptibility to coeliac disease (CD) in these subjects. We investigated 240 siblings of diabetic children from 213 families (125 males and 115 females, aged 12.6+/-4.9 years, mean +/- SD). All subjects were tested for the total IgA level to exclude IgA deficiency, and for endomysium IgA to disclose CD. In five IgA-deficient subjects, anti-gliadin IgG was used instead. Small bowel biopsy was offered to subjects with confirmed positive EMA. The HLA-DQA1, -DQB1 genotypes were determined using PCR-SSP. Positive EMA were found in 9/240 (3.8%) subjects (three males, six females). The biopsy confirmed CD in six children, two had a normal mucosal finding and one refused the biopsy. The HLA-DQ2 polymorphism was more frequent among siblings with EMA (seven of nine) than in siblings without EMA (33%), corrected P = 0.031. CONCLUSION: The 3.8% frequency of coeliac disease found in siblings of diabetic children is close to the 4.3% found previously in Czech children with type 1 diabetes mellitus and is substantially higher than the rate in the healthy children population.
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