Plasma ghrelin levels in patients with end-stage renal disease
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15588149
PII: 538
Knihovny.cz E-resources
- MeSH
- Kidney Failure, Chronic blood MeSH
- Renal Dialysis MeSH
- Ghrelin MeSH
- Insulin-Like Growth Factor Binding Protein 3 metabolism MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Insulin metabolism MeSH
- Creatinine blood MeSH
- Leptin blood MeSH
- Receptors, Leptin MeSH
- Middle Aged MeSH
- Humans MeSH
- Human Growth Hormone metabolism MeSH
- Peptide Hormones blood MeSH
- Insulin-Like Growth Factor Binding Protein 1 metabolism MeSH
- Insulin-Like Growth Factor Binding Protein 6 metabolism MeSH
- Receptors, Cell Surface metabolism MeSH
- Aged MeSH
- Body Composition physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ghrelin MeSH
- Insulin-Like Growth Factor Binding Protein 3 MeSH
- Insulin-Like Growth Factor I MeSH
- Insulin MeSH
- Creatinine MeSH
- Leptin MeSH
- Receptors, Leptin MeSH
- Human Growth Hormone MeSH
- Peptide Hormones MeSH
- Insulin-Like Growth Factor Binding Protein 1 MeSH
- Insulin-Like Growth Factor Binding Protein 6 MeSH
- Receptors, Cell Surface MeSH
Ghrelin is an acylated peptide stimulating secretion of the growth hormone (GH). It was originally isolated from the rat stomach as an endogenous ligand for the growth hormone secretagogue receptor. Although being predominantly produced by endocrine cells of the gastric fundus, its secretion has been found in various tissues including the kidney. To study the influence of renal failure on plasma ghrelin levels we examined 16 patients with end-stage renal disease (ESRD) receiving hemodialysis (8 men and 8 women) and 19 controls (10 men and 9 women). Both groups were comparable in age and BMI. In all subjects we assessed plasma levels of ghrelin, leptin, soluble leptin receptor, insulin, IGF-I, IGFBP-1, IGFBP-3 and IGFBP-6. Ghrelin levels were significantly higher in the group of dialyzed patients (4.49+/-0.74 vs. 1.79+/-0.15 ng/ml; p<0.001). These patients had significantly higher levels of GH, IGFBP-1, IGFBP-6, leptin and percentage of body fat (p<0.05). In the group of patients with ESRD plasma ghrelin levels positively correlated with IGFBP-1 (p<0.01). In the control group, ghrelin positively correlated with GH concentrations (p<0.01) and negatively correlated with the levels of insulin and creatinine (p<0.05). In conclusion, patients with ESRD have higher ghrelin concentrations, which might be caused by a decreased excretion/metabolism of ghrelin in the kidney during renal failure.
