Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15598689
DOI
10.1210/jc.2004-1364
PII: jc.2004-1364
Knihovny.cz E-resources
- MeSH
- Adiponectin MeSH
- Bulimia metabolism MeSH
- Hormones, Ectopic blood MeSH
- Homeostasis MeSH
- Body Mass Index MeSH
- Insulin blood MeSH
- Blood Glucose MeSH
- Leptin metabolism MeSH
- Receptors, Leptin MeSH
- Humans MeSH
- Anorexia Nervosa classification metabolism MeSH
- Intercellular Signaling Peptides and Proteins blood MeSH
- Receptors, Cell Surface metabolism MeSH
- Resistin MeSH
- Adipose Tissue metabolism MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adiponectin MeSH
- Hormones, Ectopic MeSH
- Insulin MeSH
- Blood Glucose MeSH
- Leptin MeSH
- Receptors, Leptin MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Receptors, Cell Surface MeSH
- Resistin MeSH
- RETN protein, human MeSH Browser
To study the role of adipose tissue-derived hormones in the pathophysiology of eating disorders, circulating levels of adiponectin, resistin, and other hormonal and metabolic parameters were measured in 16 females with the restrictive subtype of anorexia nervosa (R-AN), 10 females with the binge/purge subtype of anorexia nervosa (P-AN), 15 females with bulimia nervosa (BN), and 12 age-matched healthy females (C). Body mass index (BMI), body fat content, and serum leptin levels were severely decreased in R-AN and moderately decreased in P-AN patients, whereas the BN group did not differ from C in these parameters. Serum soluble leptin receptor levels were increased in R-AN and P-AN and unchanged in BN patients. Circulating adiponectin levels were inversely related to BMI and were unchanged in BN patients and increased by 53% in P-AN and by 96% in R-AN relative to C group, respectively. In contrast, resistin levels in malnourished R-AN and P-AN were not different from either C or BN groups and showed no significant relationship to BMI or body fat content. We suggest that increased adiponectin levels reflect decreased body fat content in AN patients. In contrast, circulating resistin levels do not appear to be closely related to the nutritional status.
References provided by Crossref.org
