Ultrasenzitivne merený C-reaktivní protein--nový parametr kardiovaskulárního rizika
[An ultrasensitive C-reactive protein assay--a new parameter in cardiovascular risk]
Language Czech Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15648966
- MeSH
- Arteriosclerosis diagnosis MeSH
- Biomarkers blood MeSH
- C-Reactive Protein analysis physiology MeSH
- Immunoassay methods MeSH
- Cardiovascular Diseases diagnosis prevention & control MeSH
- Humans MeSH
- Metabolic Syndrome diagnosis MeSH
- Nephelometry and Turbidimetry MeSH
- Risk Factors MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biomarkers MeSH
- C-Reactive Protein MeSH
Elevated C-reactive protein concentration, measured by an ultrasensitive method (hsCRP), has been proved to be a risk factor for atherosclerosis progression and its complications (myocardial infarction and stroke) in otherwise healthy men and women. In patients with already diagnosed atherosclerotic disease elevated concentration of hsCRP predicts prognosis. There are multiple causes of elevated hsCRP concentration: metabolic changes (e.g. as a part of metabolic syndrome), genetic background and chronic infections. Proinflammatory effect of adipose tissue in obese individuals seems to play an important role, hsCRP levels correlate with markers of abdominal obesity. Elevated hsCRP concentrations can be lowered both pharmacologically and by a lifestyle change. This review covers current knowledge of pathophysiology of elevated hsCRP concentration and possible use of this method in clinical medicine.
