Clear cell type of renal cell carcinoma with numerous hyaline globules: a diagnostic pitfall
Language English Country Australia Media print
Document type Case Reports, Journal Article
PubMed
15743324
DOI
10.1111/j.1440-1827.2005.01805.x
PII: PIN1805
Knihovny.cz E-resources
- MeSH
- Cytoplasm metabolism ultrastructure MeSH
- DNA, Neoplasm analysis MeSH
- DNA Primers chemistry MeSH
- Hyalin metabolism ultrastructure MeSH
- Carcinoma, Renal Cell diagnosis genetics metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- RNA, Messenger genetics metabolism MeSH
- Molecular Sequence Data MeSH
- Tumor Suppressor Proteins genetics metabolism MeSH
- Von Hippel-Lindau Tumor Suppressor Protein MeSH
- Kidney Neoplasms diagnosis genetics metabolism MeSH
- Nephrectomy MeSH
- Frameshift Mutation MeSH
- RNA, Neoplasm analysis MeSH
- Amino Acid Sequence MeSH
- Base Sequence MeSH
- Sequence Analysis, RNA MeSH
- Spironolactone metabolism MeSH
- Ubiquitin-Protein Ligases genetics metabolism MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- DNA, Neoplasm MeSH
- DNA Primers MeSH
- RNA, Messenger MeSH
- Tumor Suppressor Proteins MeSH
- Von Hippel-Lindau Tumor Suppressor Protein MeSH
- RNA, Neoplasm MeSH
- Spironolactone MeSH
- Ubiquitin-Protein Ligases MeSH
- VHL protein, human MeSH Browser
A unique and never-before-published example of clear cell renal cell carcinoma (CRCC) found among 9000 primary renal cell tumors is presented. The tumor contained such a dense concentration of glassy hyaline globules (GHG) in the cytoplasm of the neoplastic cells that it overshadowed the morphology of the neoplasm. The resulting appearance of the tumor was quite misleading and different from the conventional CRCC. The GHG were 7-30 microm in diameter. They were glassy and pale to slightly eosinophilic in color in hematoxylin-eosin. The GHG stained positively with periodic acid-Schiff and negatively with silver and Hale's colloidal iron. Immunohistochemically, they were also negative for anti Mycobacterium bovis antigen. At the ultrastructural level, the GHG were formed by an amorphous mass of stellate shape. The GHG were localized within rough endoplasmic reticulum. Molecular genetically, mutation of the distal part of exon 3 of the VHL gene causing elongation of the VHL protein was found in the tumor, thus confirming the diagnosis of CRCC.
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