Clear cell type of renal cell carcinoma with numerous hyaline globules: a diagnostic pitfall
Jazyk angličtina Země Austrálie Médium print
Typ dokumentu kazuistiky, časopisecké články
PubMed
15743324
DOI
10.1111/j.1440-1827.2005.01805.x
PII: PIN1805
Knihovny.cz E-zdroje
- MeSH
- cytoplazma metabolismus ultrastruktura MeSH
- DNA nádorová analýza MeSH
- DNA primery chemie MeSH
- hyalin metabolismus ultrastruktura MeSH
- karcinom z renálních buněk diagnóza genetika metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA genetika metabolismus MeSH
- molekulární sekvence - údaje MeSH
- nádorové supresorové proteiny genetika metabolismus MeSH
- nádorový supresorový protein VHL MeSH
- nádory ledvin diagnóza genetika metabolismus MeSH
- nefrektomie MeSH
- posunová mutace MeSH
- RNA nádorová analýza MeSH
- sekvence aminokyselin MeSH
- sekvence nukleotidů MeSH
- sekvenční analýza RNA MeSH
- spironolakton metabolismus MeSH
- ubikvitinligasy genetika metabolismus MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- DNA nádorová MeSH
- DNA primery MeSH
- messenger RNA MeSH
- nádorové supresorové proteiny MeSH
- nádorový supresorový protein VHL MeSH
- RNA nádorová MeSH
- spironolakton MeSH
- ubikvitinligasy MeSH
- VHL protein, human MeSH Prohlížeč
A unique and never-before-published example of clear cell renal cell carcinoma (CRCC) found among 9000 primary renal cell tumors is presented. The tumor contained such a dense concentration of glassy hyaline globules (GHG) in the cytoplasm of the neoplastic cells that it overshadowed the morphology of the neoplasm. The resulting appearance of the tumor was quite misleading and different from the conventional CRCC. The GHG were 7-30 microm in diameter. They were glassy and pale to slightly eosinophilic in color in hematoxylin-eosin. The GHG stained positively with periodic acid-Schiff and negatively with silver and Hale's colloidal iron. Immunohistochemically, they were also negative for anti Mycobacterium bovis antigen. At the ultrastructural level, the GHG were formed by an amorphous mass of stellate shape. The GHG were localized within rough endoplasmic reticulum. Molecular genetically, mutation of the distal part of exon 3 of the VHL gene causing elongation of the VHL protein was found in the tumor, thus confirming the diagnosis of CRCC.
Citace poskytuje Crossref.org