Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem
- MeSH
- adenom genetika metabolismus patologie MeSH
- biologické markery metabolismus MeSH
- epitelové buňky patologie MeSH
- keratin-20 metabolismus MeSH
- keratin-7 metabolismus MeSH
- keratiny metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mucin 1 metabolismus MeSH
- mutace MeSH
- nádorový supresorový protein VHL genetika MeSH
- nádory ledvin genetika metabolismus patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vimentin metabolismus MeSH
- ztráta heterozygozity MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- CAM 5.2 antigen MeSH Prohlížeč
- keratin-20 MeSH
- keratin-7 MeSH
- keratiny MeSH
- mucin 1 MeSH
- nádorový supresorový protein VHL MeSH
- VHL protein, human MeSH Prohlížeč
- vimentin MeSH
We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.
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Ultrastruct Pathol. 1988 Jan-Feb;12(1):131-6 PubMed
Am J Surg Pathol. 2000 Jul;24(7):958-70 PubMed
Eur Urol. 1987;13(4):276-80 PubMed
Br J Urol. 1977 Nov;49(6):441-6 PubMed
Pathol Int. 2005 Mar;55(3):150-4 PubMed
Pathol Res Pract. 2000;196(4):275-6 PubMed
Am J Surg Pathol. 2008 Aug;32(8):1239-45 PubMed
Virchows Arch. 2005 Sep;447(3):669-71 PubMed
Ann Diagn Pathol. 2000 Oct;4(5):311-5 PubMed
Pathol Res Pract. 1993 Sep;189(8):951-6; discussion 957-9 PubMed
Virchows Arch. 2004 Oct;445(4):359-67 PubMed
Radiology. 1983 Feb;146(2):309-21 PubMed
Am J Surg Pathol. 2004 Jul;28(7):962-6 PubMed
Virchows Arch. 2001 Nov;439(5):700-2 PubMed
Am J Surg Pathol. 2008 Mar;32(3):377-82 PubMed
Virchows Arch. 2003 Aug;443(2):220-1 PubMed
Pathol Res Pract. 1998;194(6):445-8 PubMed
J Clin Pathol. 2007 Jan;60(1):98-100 PubMed
Am J Surg Pathol. 2000 Feb;24(2):203-10 PubMed
Am J Surg Pathol. 2006 Nov;30(11):1372-81 PubMed
Ann Diagn Pathol. 1998 Feb;2(1):12-8 PubMed
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