Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
15841900
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa chemie metabolismus fyziologie MeSH
- Alzheimerova nemoc metabolismus patofyziologie MeSH
- butyrylcholinesterasa chemie metabolismus fyziologie MeSH
- lidé MeSH
- neurotransmiterové látky fyziologie MeSH
- periferní nervový systém fyziologie MeSH
- receptory cholinergní klasifikace fyziologie MeSH
- stárnutí fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- butyrylcholinesterasa MeSH
- neurotransmiterové látky MeSH
- receptory cholinergní MeSH
The serine hydrolases and proteases are a ubiquitous group of enzymes that is fundamental to many critical life-functions. Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyrylcholinesterase remains unknown. Acetylcholinesterase is one of the crucial enzymes in the central and peripheral nerve system. Organophosphates and carbamates are potent inhibitors of serine hydrolases and well suited probes for investigating the chemical reaction mechanism of the inhibition. Understanding the enzyme's chemistry is essential in preventing and/or treating organophosphate and carbamate poisoning as well as designing new medicaments for cholinergic-related diseases like as Alzheimer's disease.
