Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body
Language English Country Czech Republic Media print
Document type Journal Article, Review
PubMed
15841900
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase chemistry metabolism physiology MeSH
- Alzheimer Disease metabolism physiopathology MeSH
- Butyrylcholinesterase chemistry metabolism physiology MeSH
- Humans MeSH
- Neurotransmitter Agents physiology MeSH
- Peripheral Nervous System physiology MeSH
- Receptors, Cholinergic classification physiology MeSH
- Aging physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Butyrylcholinesterase MeSH
- Neurotransmitter Agents MeSH
- Receptors, Cholinergic MeSH
The serine hydrolases and proteases are a ubiquitous group of enzymes that is fundamental to many critical life-functions. Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyrylcholinesterase remains unknown. Acetylcholinesterase is one of the crucial enzymes in the central and peripheral nerve system. Organophosphates and carbamates are potent inhibitors of serine hydrolases and well suited probes for investigating the chemical reaction mechanism of the inhibition. Understanding the enzyme's chemistry is essential in preventing and/or treating organophosphate and carbamate poisoning as well as designing new medicaments for cholinergic-related diseases like as Alzheimer's disease.
