TEL/AML1 and immunoreceptor gene rearrangements-which comes first?
Language English Country Great Britain, England Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15863202
DOI
10.1016/j.leukres.2004.11.007
PII: S0145-2126(04)00392-3
Knihovny.cz E-resources
- MeSH
- Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnosis genetics MeSH
- B-Lymphocytes immunology MeSH
- Cell Cycle genetics MeSH
- Oncogene Proteins, Fusion genetics MeSH
- Gene Rearrangement MeSH
- Hematopoietic Stem Cells immunology MeSH
- Immunophenotyping MeSH
- Immunoglobulins analysis genetics MeSH
- Humans MeSH
- Neprilysin biosynthesis immunology MeSH
- Core Binding Factor Alpha 2 Subunit MeSH
- Receptors, Antigen, T-Cell analysis genetics MeSH
- Receptors, Immunologic analysis genetics MeSH
- Recurrence MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Oncogene Proteins, Fusion MeSH
- Immunoglobulins MeSH
- Neprilysin MeSH
- Core Binding Factor Alpha 2 Subunit MeSH
- Receptors, Antigen, T-Cell MeSH
- Receptors, Immunologic MeSH
- TEL-AML1 fusion protein MeSH Browser
TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+ immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process.
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