Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15922050
DOI
10.1016/j.bbr.2005.02.012
PII: S0166-4328(05)00059-8
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Muscarinic Antagonists administration & dosage MeSH
- Maze Learning drug effects MeSH
- Time Factors MeSH
- Behavior, Animal drug effects MeSH
- Rats MeSH
- Motor Activity drug effects MeSH
- Rats, Long-Evans MeSH
- Spatial Behavior drug effects MeSH
- Retention, Psychology drug effects MeSH
- Mental Recall drug effects MeSH
- Drug Administration Schedule MeSH
- Scopolamine administration & dosage MeSH
- Avoidance Learning drug effects MeSH
- Space Perception drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Muscarinic Antagonists MeSH
- Scopolamine MeSH
Animal navigation to hidden goals (place navigation) ranks among the most intensively studied types of behaviour because it requires brain representations of environments in the form of cognitive maps, demonstrated to depend on hippocampal function. Intact function of muscarinic receptors in the brain was originally assumed to be crucial for place navigation, however, recent studies using non-spatial pretraining demonstrated that animals with central blockade of muscarinic acetylcholine receptors can also learn and retrieve spatial memory engrams. In the present study we addressed whether navigation in the active allothetic place avoidance (AAPA) task, which requires animals to separate spatial stimuli into coherent representations and navigate according to the representation relevant for the task, is dependent on intact muscarinic receptors in the brain. We studied the effect of three doses of scopolamine (0.5, 1.0 and 2.0mg/kg) administered 20 min prior to training on the retention of the AAPA and re-acquisition of the AAPA in a new environment. The dose of 2.0mg/kg was found to impair both AAPA retention and re-acquisition of the AAPA in a new environment, whereas the 1.0mg/kg dose only impaired the reinforced retention of AAPA. It is concluded that, unlike navigation in classic paradigms, efficient orientation in the AAPA task is critically dependent on muscarinic receptors in the brain.
References provided by Crossref.org
Chemogenetic Tools and their Use in Studies of Neuropsychiatric Disorders
Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat
Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation
