Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
17-04047S
Grantová Agentura České Republiky - International
RVO: 67985823
Akademie Věd České Republiky - International
PubMed
29680966
DOI
10.1007/s00213-018-4899-3
PII: 10.1007/s00213-018-4899-3
Knihovny.cz E-resources
- Keywords
- Anticholinergics, Learning, Memory, Morris water maze, Muscarinic receptors, Rat,
- MeSH
- Alzheimer Disease psychology MeSH
- Muscarinic Antagonists pharmacology MeSH
- Biperiden pharmacology MeSH
- Maze Learning drug effects MeSH
- Behavior, Animal drug effects MeSH
- Cognitive Dysfunction psychology MeSH
- Memory, Short-Term drug effects MeSH
- Rats * MeSH
- Disease Models, Animal * MeSH
- Memory Disorders psychology MeSH
- Rats, Wistar MeSH
- Reversal Learning drug effects MeSH
- Animals MeSH
- Check Tag
- Rats * MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Muscarinic Antagonists MeSH
- Biperiden MeSH
RATIONALE: There is a persistent pressing need for valid animal models of cognitive and mnemonic disruptions (such as seen in Alzheimer's disease and other dementias) usable for preclinical research. OBJECTIVES: We have set out to test the validity of administration of biperiden, an M1-acetylcholine receptor antagonist with central selectivity, as a potential tool for generating a fast screening model of cognitive impairment, in outbred Wistar rats. METHODS: We used several variants of the Morris water maze task: (1) reversal learning, to assess cognitive flexibility, with probe trials testing memory retention; (2) delayed matching to position (DMP), to evaluate working memory; and (3) "counter-balanced acquisition," to test for possible anomalies in acquisition learning. We also included a visible platform paradigm to reveal possible sensorimotor and motivational deficits. RESULTS: A significant effect of biperiden on memory acquisition and retention was found in the counter-balanced acquisition and probe trials of the counter-balanced acquisition and reversal tasks. Strikingly, a less pronounced deficit was observed in the DMP. No effects were revealed in the reversal learning task. CONCLUSIONS: Based on our results, we do not recommend biperiden as a reliable tool for modeling cognitive impairment.
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