Systemic and local antibody responses after experimental infection with Actinobacillus pleuropneumoniae in piglets with passive or active immunity
Jazyk angličtina Země Německo Médium print
Typ dokumentu klinické zkoušky, časopisecké články, randomizované kontrolované studie, práce podpořená grantem
PubMed
16000115
DOI
10.1111/j.1439-0450.2005.00844.x
PII: JVB844
Knihovny.cz E-zdroje
- MeSH
- Actinobacillus pleuropneumoniae imunologie MeSH
- bronchoalveolární lavážní tekutina imunologie MeSH
- ELISA veterinární MeSH
- imunita získaná od matky * MeSH
- imunoglobulin A biosyntéza MeSH
- infekce bakteriemi rodu Actinobacillus imunologie veterinární MeSH
- kolostrum imunologie MeSH
- lipopolysacharidy MeSH
- nemoci prasat krev imunologie mikrobiologie MeSH
- novorozená zvířata MeSH
- prasata MeSH
- protilátky bakteriální biosyntéza MeSH
- těhotenství MeSH
- zvířata MeSH
- Check Tag
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- imunoglobulin A MeSH
- lipopolysacharidy MeSH
- protilátky bakteriální MeSH
The objectives of the present study was to describe different dynamics of humoral immune responses to experimental infection in piglets of different stages of infection and immunity. Two groups of piglets originating from non-immune (group 1) and immune (group 2) sows at the age of 3 weeks were subdivided as follows: a half of each group of piglets was exposed to a low-dose infection with Actinobacillus pleuropneumoniae (APP) strain 9. At the age of 8 weeks, all four groups of piglets were challenged with a high infection dose of APP of the same strain. Isotype characterization of the specific antibodies in sera and in bronchoalveolar lavage fluids (BALF) to a lipopolysaccharide was carried out, besides monitoring clinical signs and post-mortem examinations. A typical primary immune response was observed in specific antibody-free piglets infected with a challenge infection. Colostrum-derived immunoglobulin-G (IgG) antibodies persisted in sera and BALF of piglets up to the age of 8 weeks. However, they did not prevent induction of specific-primary antibody response, either in 8 or 4 weeks of age, when levels of specific colostrum-derived antibodies were still high. It was demonstrated by the increase of specific IgM antibodies in sera. The infection induced an increase in the levels of IgA antibodies in BALF regardless the severity of infection and presence of specific colostrum-derived antibodies. The specific antibodies of IgG isotype increased only in BALF from piglets without colostrum-derived antibodies.
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