Humoral intestinal immunity against Encephalitozoon cuniculi (Microsporidia) infection in mice
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
16004375
DOI
10.14411/fp.2005.020
Knihovny.cz E-zdroje
- MeSH
- ELISA MeSH
- Encephalitozoon cuniculi imunologie MeSH
- encephalitozoonóza imunologie MeSH
- imunoglobulin A krev MeSH
- imunoglobulin G krev MeSH
- imunoglobulin M krev MeSH
- myši inbrední BALB C MeSH
- myši knockoutované MeSH
- myši MeSH
- protilátky fungální imunologie MeSH
- spory hub imunologie MeSH
- střeva mikrobiologie MeSH
- tvorba protilátek imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- imunoglobulin A MeSH
- imunoglobulin G MeSH
- imunoglobulin M MeSH
- protilátky fungální MeSH
Three strains of mice, BALB/c, IL-12 knock-out (KO) and INF-gamma knock-out, were chosen as an experimental model for the study of intestinal immunity induction against Encephalitozoon cuniculi Levaditi, Nicolau et Schoen, 1923 infection. Mice were infected perorally with 10(7) spores and re-infected with the same dose 70 days after the first infection. The anti-E. cuniculi IgA, IgG and IgM responses in sera and extracts of stool samples were determined by ELISA. Results have shown specific antibody production in the sera and intestinal secretions of all three strains of mice induced orally by E. ciniculi spores. BALB/c mice developed a stronger humoral immune response than IL-12 KO mice. The lowest antibody response developed in INF-gamma KO mice that succumbed to the infection within 28 days post infection.
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