Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16441507
DOI
10.1111/j.1365-3024.2005.00813.x
PII: PIM813
Knihovny.cz E-resources
- MeSH
- Survival Analysis MeSH
- CD4-Positive T-Lymphocytes immunology MeSH
- Encephalitozoon cuniculi immunology MeSH
- Encephalitozoonosis immunology therapy MeSH
- Immunotherapy methods MeSH
- Antibodies, Monoclonal immunology pharmacology MeSH
- Mice, Inbred BALB C MeSH
- Mice, SCID MeSH
- Mice MeSH
- Statistics, Nonparametric MeSH
- Spores, Fungal immunology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antibodies, Monoclonal MeSH
The role of antibodies in the immune response to microsporidiosis was studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ reconstituted, perorally infected and intraperitoneally MAb-treated SCID mice. The MAb decreased the numbers of E. cuniculi spores in peritoneal smears obtained post mortem. These results suggest a possible role for antibodies in protection against perorally acquired E. cuniculi infection.
References provided by Crossref.org
Chronic Infections in Mammals Due to Microsporidia
