The influence of oxime and anticholinergic drug selection on the potency of antidotal treatment to counteract acute toxic effects of tabun in mice
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
16464753
DOI
10.1007/bf03033308
Knihovny.cz E-resources
- MeSH
- Antidotes pharmacology MeSH
- Chemical Warfare Agents poisoning MeSH
- Cholinergic Antagonists pharmacology MeSH
- Drug Evaluation MeSH
- Lethal Dose 50 MeSH
- Drug Interactions MeSH
- Mice MeSH
- Organophosphates antagonists & inhibitors MeSH
- Organophosphate Poisoning MeSH
- Oximes pharmacology MeSH
- Cholinesterase Reactivators therapeutic use MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Antidotes MeSH
- Chemical Warfare Agents MeSH
- Cholinergic Antagonists MeSH
- Organophosphates MeSH
- Oximes MeSH
- Cholinesterase Reactivators MeSH
- tabun MeSH Browser
The influence of newly developed oximes, K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide] and K048 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) butane dibromide], or currently used oximes (pralidoxime, obidoxime, trimedoxime, HI-6) and anticholinergic drugs (atropine, benactyzine) on the ability of antidotal treatment to eliminate tabun-induced acute toxic effects was studied in mice. The therapeutical efficacy of trimedoxime and both newly developed oximes (K027, K048) is significantly higher than the potency of pralidoxime (regardless of the choice of anticholinergic drug), obidoxime (in the case of its combination with atropine) and the oxime HI-6 (in the case of its combination with benactyzine). All studied oximes with the exception of pralidoxime and the oxime HI-6, when combined with benactyzine, appear to be more efficacious in the elimination of toxic effects of the lethal dose of tabun than their combination with atropine. The findings support the hypothesis that the choice of acetylcholinesterase reactivators as well as the anticholinergic drug selection are important for the effectiveness of an antidotal mixture in the case of antidotal treatment of tabun-induced acute poisonings.
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