The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis
Language English Country Switzerland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16534198
DOI
10.1159/000091966
PII: 91966
Knihovny.cz E-resources
- MeSH
- Carotid Artery, Common diagnostic imaging pathology MeSH
- Bilirubin blood MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Gilbert Disease blood pathology MeSH
- Liver Function Tests MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Tunica Intima diagnostic imaging pathology MeSH
- Tunica Media diagnostic imaging pathology MeSH
- Ultrasonography MeSH
- Age Factors MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bilirubin MeSH
- Biomarkers MeSH
BACKGROUND: Serum bilirubin is negatively associated with the development of coronary heart disease. In the present study, we have focused on the analysis of intima-media thickness (IMT) of the common carotid artery in hyper- and normobilirubinemic subjects. METHODS: The study was performed on 111 men without manifested atherosclerosis. In all subjects, complete biochemical tests were determined along with the examination of IMT by carotid ultrasound. RESULTS: The mean IMT in hyperbilirubinemic subjects as compared with controls was substantially lower (p=0.017), and hyperbilirubinemic men also had very low age-adjusted prevalence odds ratios for having IMT above the 50th percentiles of controls, even after adjustment for selected vascular risk factors (p=0.034). CONCLUSIONS: In the present study, we demonstrate the inverse relationship between serum bilirubin and IMT in healthy men.
References provided by Crossref.org
Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis
The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases
