Increased antioxidant capacity of serum did not prevent lipid peroxidation in the intermittent ischemia-reperfusion of rat small intestine
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Analysis of Variance MeSH
- Antioxidants analysis metabolism MeSH
- Ischemia physiopathology MeSH
- Rats MeSH
- Luminescent Measurements MeSH
- Mesenteric Vascular Occlusion blood physiopathology MeSH
- Disease Models, Animal MeSH
- Random Allocation MeSH
- Lipid Peroxidation physiology MeSH
- Rats, Wistar MeSH
- Reperfusion Injury blood physiopathology MeSH
- Risk Factors MeSH
- Sensitivity and Specificity MeSH
- Intestine, Small blood supply MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Antioxidants MeSH
Changes in small molecular antioxidants were followed up in a model of small intestinal ischemia in Wistar rats to evaluate their possible role in ischemic preconditioning. The superior mesenteric artery was occluded either for 60 minutes only or for 60 minutes preceded by one to three 15-minute periods of ischemia with 5-minute reperfusion periods interposed. Total antioxidant capacity (TRAP) in serum, serum antioxidants (uric acid, ascorbic acid, bilirubin), and the thiobarbituric acid reactive substances in both serum and mucosa were measured. An increase in TRAP observed after 60 minutes of ischemia was prevented in preconditioned animals. Ascorbic and uric acid concentrations increased generally in comparison to intact controls, but this increase was not sufficient to prevent lipid peroxidation in serum and intestinal mucosa. In short, the small molecular antioxidants measured did not contribute to the phenomenon of ischemic preconditioning.
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